Attention deficit hyperactivity disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Additionally, we investigated the effect of Adgrl3-depletion at the transcriptomic level by RNA-sequencing three ADHD-relevant brain regions: prefrontal cortex (PFC), hippocampus and striatum.
|
30849401 |
2019 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The overall evidence from the literature, corroborated by our results, suggests that ADGRL3 might be involved in brain development, and genetic modifications related to it might be part of a shared vulnerability factor associated with the underlying neurobiology of neurodevelopmental disorders such as ADHD and ASD.
|
30652248 |
2019 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
As the first study to comprehensively explore the role of LPHN3 in ADHD in Chinese children, our research suggests that LPHN3 gene has a significant effect on the ADHD in a Chinese population.
|
30406846 |
2019 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using family-based, case-control, and longitudinal samples from disparate regions of the world (n = 2698), recruited either for clinical, genetic epidemiological or pharmacogenomic studies of ADHD, we assembled recursive-partitioning frameworks (classification tree analyses) with clinical, demographic, and ADGRL3 genetic information to predict SUD susceptibility.
|
30696812 |
2019 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the gene coding for the adhesion G-protein coupled receptor LPHN3 are a risk factor for attention-deficit/hyperactivity disorder (ADHD).
|
29496512 |
2018 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Latrophilin 3 (Lphn3), which is associated with ADHD in human populations and is involved in synapse structure, and its ligand fibronectin leucine rich transmembrane protein 3 (Flrt3), were downregulated in High-Active mice.
|
30110355 |
2018 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the group composed by predominantly hyperactive/impulsive and combined presentation, the presence of LPHN3-rs6551665 G allele was related to increased ADHD risk only in individuals carrying the TTC12-rs2303380 AA genotype (p=0.026).
|
28624582 |
2017 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have reported linkage and association to ADHD of gene variants within ADGRL3.
|
27692237 |
2016 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report evidence of the genetic contribution of common variants to the ADHD phenotype in four genes, with the LPHN3 gene playing a particularly important role.
|
26746237 |
2016 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we examined the association between the LPHN3 rs6551665 A/G polymorphism and ADHD in Korea.
|
25871512 |
2015 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The association between LPHN3 and ADHD was evaluated in 523 children and adolescents with ADHD and 132 controls.
|
25989180 |
2015 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association of SNAP-25, SLC6A2, and LPHN3 with OROS methylphenidate treatment response in attention-deficit/hyperactivity disorder.
|
25229170 |
2015 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the 4q13.1 linkage peak (lod 2.34) occurred immediately upstream of the LPHN3 gene, recently reported both linked and associated with ADHD.
|
23190410 |
2013 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results of our study further strengthen the concept of an LPHN3 risk haplotype for ADHD and support the usefulness of the endophenotype approach in psychiatric and psychological research.
|
23245769 |
2013 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The substantial heritability of ADHD is well documented and recent genome-wide analyses for risk genes revealed synaptic adhesion molecules (e.g. latrophilin-3, LPHN3; fibronectin leucine-rich repeat transmembrane protein-3, FLRT3), glutamate receptors (e.g. metabotropic glutamate receptor-5, GRM5) and mediators of intracellular signalling pathways (e.g. nitric oxide synthase-1, NOS1).
|
22939004 |
2013 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
As we have identified that common variants of the LPHN3 gene were responsible for the 4q linkage signal, we focused on 4q-11q interaction to determine that single-nucleotide polymorphisms (SNPs) harbored in the LPHN3 gene interact with SNPs spanning the 11q region that contains DRD2 and NCAM1 genes, to double the risk of developing ADHD.
|
21606926 |
2012 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
Mutations in LPHN3 are strongly associated with attention deficit hyperactivity disorder, suggesting a role for latrophilins in human cognitive function.
|
22405201 |
2012 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results of our study confirm the hypothesis that LPHN3 is associated with response to MPH in ADHD children.
|
22851411 |
2012 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found that SNPs within the LPHN3 gene interact with SNPs spanning the 11q region that contains DRD2 and NCAM1 not only to increase the risk of developing ADHD but also to increase ADHD severity.
|
22832519 |
2011 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, we identified LPHN3, a novel ADHD susceptibility gene harbored in 4q, and showed that a LPHN3 common haplotype confers susceptibility to ADHD and predicts effectiveness of stimulant medication.
|
21184580 |
2011 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results further support the LPHN3 contribution to combined type ADHD, and specifically to the persistent form of the disorder, and point at this new neuronal pathway as a common susceptibility factor for ADHD throughout the lifespan.
|
21040458 |
2011 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Linkage and replicated association of ADHD with a novel non-candidate gene (LPHN3) provide new insights into the genetics, neurobiology, and treatment of ADHD.
|
20157310 |
2010 |