|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease.
|
23041938 |
2013 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest a modest role for KIBRA as a cognition and AD risk gene, and also highlight the multifactorial complexity of its genetic associations.
|
21185624 |
2011 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that KIBRA is associated with both individual variation in normal episodic memory and predisposition to AD.
|
18789830 |
2010 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results evidence a strong association between the KIBRA gene and episodic memory impairment in AD, but show no influence on AD in our Japanese cohort.
|
20881395 |
2010 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The first genome-wide association study of human memory identified an association between a common T/C polymorphism of the KIBRA gene (rs17070145) and episodic memory performance in normal individuals; subsequent studies have implicated the same polymorphism in Alzheimer's disease.
|
20185150 |
2010 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p=0.03) for very-late-onset (after the age of 86 years) AD.
|
17707552 |
2009 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our Cross-sectional investigation of 312 adults aged 50-89 years free of dementia included genotyping of the KIBRA rs17070145 gene and the assessment of episodic memory to Establish a Registry for Alzheimer's Disease (CERAD).
|
18194457 |
2009 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have implicated the involvement of a genetic variation in the KIBRA gene (T allele) in human memory in normal subjects and in the risk of developing Alzheimer's disease (AD).
|
18378080 |
2008 |
|
MEMORY QUANTITATIVE TRAIT LOCUS
|
0.100 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
Malignant neoplasm of breast
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Compared to those with high expression, patients with low WWC1 had higher risk of breast cancer relapse [hazard ratio (HR) = 2.06, 95% confidence interval (CI): 1.26-3.37] and higher risk of death (HR = 2.76, 95% CI: 1.51-5.03).
|
31102318 |
2019 |
|
Malignant neoplasm of breast
|
0.080 |
Biomarker
|
disease |
BEFREE |
Here, we discuss a comprehensive knowledge about the KIBRA protein, its domains and the interacting partners involved in metastasis of breast cancer.
|
30977035 |
2019 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Our results showed that low expression of WWC1 was significantly associated with advanced-stage diseases, high-grade tumors, and estrogen receptor- or progesterone receptor-negative status.
|
31102318 |
2019 |
|
Breast Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Here, we discuss a comprehensive knowledge about the KIBRA protein, its domains and the interacting partners involved in metastasis of breast cancer.
|
30977035 |
2019 |
|
Breast Carcinoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Compared to those with high expression, patients with low WWC1 had higher risk of breast cancer relapse [hazard ratio (HR) = 2.06, 95% confidence interval (CI): 1.26-3.37] and higher risk of death (HR = 2.76, 95% CI: 1.51-5.03).
|
31102318 |
2019 |
|
Malignant neoplasm of breast
|
0.080 |
PosttranslationalModification
|
disease |
BEFREE |
Both bisulfite sequencing and MeDIP demonstrated higher CpG methylation of the wwc1 promoter the TNBC cells (MDA-MB-231) than in luminal breast cancer cells (MCF7).
|
30121333 |
2018 |
|
Malignant neoplasm of breast
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Moreover, WWC1 was identified as the most important genetic susceptibility locus highlighting the importance of genetic epidemiology studies of breast cancer in understudied populations.
|
29873413 |
2018 |
|
Malignant neoplasm of breast
|
0.080 |
Biomarker
|
disease |
BEFREE |
Overall KIBRA-low breast cancers accounted for 41.5%.
|
29793439 |
2018 |
|
Malignant neoplasm of breast
|
0.080 |
Biomarker
|
disease |
BEFREE |
In summary, this study elucidates the molecular events that underpin the role of KIBRA in BC.
|
30042827 |
2018 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Our current study aimed to design an artificial transcription factor capable of re-activating expression of the tumor suppressor KIBRA and the hippo pathway.
|
29523820 |
2018 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Mechanistically, we identify KIBRA as a major factor contributing to the effects of 5q loss on tumor growth and metastatic progression.
|
29562176 |
2018 |
|
Breast Carcinoma
|
0.080 |
PosttranslationalModification
|
disease |
BEFREE |
Both bisulfite sequencing and MeDIP demonstrated higher CpG methylation of the wwc1 promoter the TNBC cells (MDA-MB-231) than in luminal breast cancer cells (MCF7).
|
30121333 |
2018 |
|
Breast Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
KIBRA; a novel biomarker predicting recurrence free survival of breast cancer patients receiving adjuvant therapy.
|
29793439 |
2018 |
|
Breast Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
In summary, this study elucidates the molecular events that underpin the role of KIBRA in BC.
|
30042827 |
2018 |
|
Breast Carcinoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Moreover, WWC1 was identified as the most important genetic susceptibility locus highlighting the importance of genetic epidemiology studies of breast cancer in understudied populations.
|
29873413 |
2018 |
|
Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, we found that KIBRA expression level goes up with increase in breast cancer progression in well-established MCF10A model system.
|
28664913 |
2017 |