|
Mental Depression
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Serum KIBRA mRNA and Protein Expression and Cognitive Functions in Depression.
|
26768155 |
2016 |
|
Depressive disorder
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Serum KIBRA mRNA and Protein Expression and Cognitive Functions in Depression.
|
26768155 |
2016 |
|
Mental Depression
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Regulation of AMPA receptor function by the human memory-associated gene KIBRA.
|
21943600 |
2011 |
|
Depressive disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Regulation of AMPA receptor function by the human memory-associated gene KIBRA.
|
21943600 |
2011 |
|
Psychotic Disorders
|
0.310 |
Biomarker
|
group |
PSYGENET |
In the unaffected individuals (patients' relatives and healthy controls) we observed an association of KIBRA with immediate and delayed logical memory (p=0.020 and 0.025, respectively), while in patients with psychosis with delayed visual memory (p=0.05).
|
20185150 |
2010 |
|
Psychotic Disorders
|
0.310 |
Biomarker
|
group |
BEFREE |
In the unaffected individuals (patients' relatives and healthy controls) we observed an association of KIBRA with immediate and delayed logical memory (p=0.020 and 0.025, respectively), while in patients with psychosis with delayed visual memory (p=0.05).
|
20185150 |
2010 |
|
Nonorganic psychosis
|
0.310 |
Biomarker
|
disease |
PSYGENET |
In the unaffected individuals (patients' relatives and healthy controls) we observed an association of KIBRA with immediate and delayed logical memory (p=0.020 and 0.025, respectively), while in patients with psychosis with delayed visual memory (p=0.05).
|
20185150 |
2010 |
|
Nonorganic psychosis
|
0.310 |
Biomarker
|
disease |
BEFREE |
In the unaffected individuals (patients' relatives and healthy controls) we observed an association of KIBRA with immediate and delayed logical memory (p=0.020 and 0.025, respectively), while in patients with psychosis with delayed visual memory (p=0.05).
|
20185150 |
2010 |
|
Malignant mesothelioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
MicroRNA and mRNA features of malignant pleural mesothelioma and benign asbestos-related pleural effusion.
|
25756049 |
2015 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Methods</b>: The AD animal model (APP/PS1 transgenic mice) and KIBRA knockout (KIBRA KO) mice were used to investigate pathophysiological changes of KIBRA <i>in vivo</i>.
|
31031595 |
2019 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that healthy older people have additive and epistatic interactions of KIBRA and APOE gene variants, which modulate brain FNC and may partly elucidate their association with episodic memory performance and AD.
|
30715155 |
2019 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Alterations of Kibra-encoding gene WWC1 cause various neuronal disorders, including Alzheimer's disease and Tourette syndrome.
|
30784589 |
2019 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There is a lack of consensus on the effect of KIBRA gene variants on cognitive performances in episodic memory and on the risk of AD.
|
30953258 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
KIBRA single nucleotide polymorphism (rs17070145) has been linked to episodic memory performance as well as an increased risk of Alzheimer's disease and post-traumatic stress disorder (PTSD).
|
30134813 |
2018 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In functional studies, WW and C2 domain containing 1, aka KIBRA and TLN2 coexpressed in the temporal cortex brain tissue of AD subjects (β=0.17, 95% CI 0.04 to 0.30, p=0.01); modulated Tau toxicity in Drosophila eye experiments; colocalized in brain tissue cells, N2a neuroblastoma, and HeLa cell lines; and coimmunoprecipitated both in brain tissue and HEK293 cells.
|
30201328 |
2018 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of KIBRA polymorphism with risk of Alzheimer's disease: Evidence based on 20 case-control studies.
|
28859866 |
2018 |
|
Microalbuminuria
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.
|
30566433 |
2018 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations of APOE and KIBRA have been associated with human memory and Alzheimer's disease.
|
27620974 |
2017 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results suggest that the effect of the WWC1 rs17070145 polymorphism on memory performance and Alzheimer's disease might be due to a differential regulation of the MAPK signaling, a key pathway involved in memory and learning processes.
|
28380666 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Functional studies suggest that KIBRA is a potential candidate gene for memory and Alzheimer's disease (AD) risk.
|
25800888 |
2015 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggested that KIBRA might associate with younger AD patients (≤74 years) in a Northern Han Chinese population.
|
24190487 |
2013 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association between KIBRA polymorphisms and the DMN and ECN should be further explored in a healthy older population and in patients with AD.
|
23266749 |
2013 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The human KIBRA gene has been linked to human cognition through a lead intronic single-nucleotide polymorphism (SNP; rs17070145) that is associated with episodic memory performance and the risk to develop Alzheimer's disease.
|
23778582 |
2013 |