|
Tendinitis
|
0.200 |
Biomarker
|
disease |
RGD |
Sustained expression of proteoglycans and collagen type III/type I ratio in a calcified tendinopathy model.
|
19955224 |
2010 |
|
Chronic Lymphocytic Leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Using Bayesian learning, the expression levels of only two genes, FMOD and PIK3C2B, correctly distinguished 100 % of CLL and MBL cases from normal polyclonal and mono/oligoclonal B lymphocytes.
|
26318878 |
2015 |
|
Chronic Lymphocytic Leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
We have previously reported on another SLRP, fibromodulin (FMOD) in patients with chronic lymphocytic leukemia (CLL).
|
23826326 |
2013 |
|
Chronic Lymphocytic Leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
We have previously demonstrated that ROR1 and FMOD (fibromodulin) are two genes upregulated in chronic lymphocytic leukaemia (CLL) cells compared to normal blood B cells.
|
20813009 |
2010 |
|
Chronic Lymphocytic Leukemia
|
0.050 |
Biomarker
|
disease |
LHGDN |
Fibromodulin, an extracellular matrix protein: characterization of its unique gene and protein expression in B-cell chronic lymphocytic leukemia and mantle cell lymphoma.
|
15741214 |
2005 |
|
Chronic Lymphocytic Leukemia
|
0.050 |
Biomarker
|
disease |
LHGDN |
In summary, FMOD was shown for the first time to be naturally processed and presented as TAA in primary CLL cells, enabling the expansion of autologous tumor-specific T cells.
|
15471955 |
2005 |
|
Chronic Lymphocytic Leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Therefore FMOD might serve as potential tumor-associated antigen (TAA) in CLL, enabling expansion of FMOD-specific T cells.
|
15471955 |
2005 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Fibromodulin can therefore be a unique effector of dense collagen matrix assembly in tumor stroma and, without affecting other major matrix components or the cellular composition, can function as a main agent in tumor barrier function.
|
28827814 |
2017 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Additionally, fibromodulin has been identified as a novel tumor-associated antigen in leukemia, lymphoma, and leiomyoma.
|
26600400 |
2016 |
|
Severe myopia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
PURPOSE.To investigate the relationship between high myopia and single nucleotide polymorphisms (SNPs) in six proteoglycan genes: aggrecan (ACAN), fibromodulin (FMOD), decorin (DCN), lumican (LUM), keratocan (KERA), and epiphycan (EPYC).
|
21743019 |
2011 |
|
Severe myopia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor-beta2 (TGF-beta2), basic fibroblast growth factor (bFGF), and fibromodulin (FMOD) are important extracellular matrix components of the sclera and have been shown to be associated with the development of high myopia.
|
19710942 |
2009 |
|
Severe myopia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Analysis of 85 English and 40 Finnish subjects with high myopia (refractive error of -6 diopters [D] or greater) resulted in 23 sequence variations in four SLRP genes, LUM, FMOD, PRELP, and OPTC.
|
17117407 |
2007 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
We screened the mRNA expression of tumor-associated antigens (TAAs) from the literature (fibromodulin, survivin, OFA-iLRP, BAGE, G250, MAGE1, PRAME, proteinase, syntaxin, hTERT, WT-1) and TAAs defined previously by serological analysis of cDNA expression libraries from leukemic cells (PINCH, HSJ2, MAZ, MPP11, RHAMM/CD168, NY-Ren60).
|
16773189 |
2006 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes.
|
15471955 |
2005 |
|
Severe myopia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We screened individuals for lumican and fibromodulin sequence alterations from the original MYP3 family, and from a second high grade myopia pedigree that showed suggestive linkage to both the MYP3 interval and to chromosome 1q32.
|
15592176 |
2004 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Moreover, we summarized the diagnostic and therapeutic applications of FMOD in cancer therapy.
|
31198406 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Our findings identify a critical role of FMOD in cancer metastasis, reveal a mechanism regulating FMOD transcription and impacting tumor metastasis, uncover action targets and mechanism for the anticancer activity of Aspirin, and expand the understanding of the Wnt/β-catenin pathway and tumor metastasis, which are valuable for development of cancer therapeutics.
|
31824307 |
2019 |
|
Degenerative polyarthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
FMOD was more prominently localized in the superficial cartilage of normal and fibrillated zones in OA cartilage.
|
30700002 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Our findings identify a critical role of FMOD in cancer metastasis, reveal a mechanism regulating FMOD transcription and impacting tumor metastasis, uncover action targets and mechanism for the anticancer activity of Aspirin, and expand the understanding of the Wnt/β-catenin pathway and tumor metastasis, which are valuable for development of cancer therapeutics.
|
31824307 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Moreover, we summarized the diagnostic and therapeutic applications of FMOD in cancer therapy.
|
31198406 |
2019 |
|
Degenerative polyarthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
The expressions of fibromodulin (FMOD), type II collagen (Col II), B-cell lymphoma-2 (Bcl-2), sex-determining region of Y chromosome (SRY)-related high-mobility group-box gene 9 (Sox9), and proliferating cell nuclear antigen (PCNA) were decreased, whereas the expressions of miR-340-5p, runt-related transcription factor-2 (Runx2), Bcl-2-associated X protein (Bax), and ERK1/2 were elevated in the OA mice.
|
30144066 |
2018 |
|
Degenerative polyarthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
We analyzed the effect of BMP-2 in both cartilage and subchondral bone in a TMJ-OA animal model that is deficient in biglycan (Bgn) and fibromodulin (Fmod) (Bgn-/-Fmod-/-).
|
28419987 |
2017 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The small leucine rich proteoglycan fibromodulin is overexpressed in human prostate epithelial cancer cell lines in culture and human prostate cancer tissue.
|
26600400 |
2016 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The small leucine rich proteoglycan fibromodulin is overexpressed in human prostate epithelial cancer cell lines in culture and human prostate cancer tissue.
|
26600400 |
2016 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Wnt/β-Catenin Pathway-Regulated Fibromodulin Expression Is Crucial for Breast Cancer Metastasis and Inhibited by Aspirin.
|
31824307 |
2019 |