|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Due to its high complexity, the KRAB-ZNF family has not been studied in sufficient detail, and the involvement of its members in carcinogenesis remains mostly unexplored.
|
30444046 |
2019 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
BORIS (CTCFL) is a DNA binding protein which is involved in tumorigenesis.
|
30323717 |
2018 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Although the distinct biological functions of most KRAB-ZNF proteins remain unknown, recent publications indicate their implication in fundamental processes, such as cell proliferation, apoptosis, differentiation, development, and tumorigenesis.
|
26738774 |
2016 |
|
Carcinogenesis
|
0.050 |
PosttranslationalModification
|
phenotype |
BEFREE |
In summary, these studies associate toxicant exposure with widespread silencing of ZNF genes by DNA hypermethylation-linked H3K9me3 spreading, further implicating epigenetic dysfunction as a driver of toxicant associated carcinogenesis.
|
23974009 |
2013 |
|
Carcinogenesis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Thus, we have identified a new member of KRAB-ZNF superfamily with growth-inhibitory ability and its downregulation may contribute to carcinogenesis.
|
17137575 |
2007 |
|
Amyotrophic Lateral Sclerosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Dominant mutations in the RNA/DNA-binding protein TDP-43 have been linked to amyotrophic lateral sclerosis (ALS).
|
31067307 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
TDP-43 (transactive- response DNA binding protein) amazes structural biologist as its aberrant ubiquitinated cytosolic inclusions is largely involved in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
|
30315897 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
In this study, we aimed to provide a comprehensive description of cancer-associated KRAB-ZNFs using publicly available The Cancer Genome Atlas pan-cancer datasets.
|
30444046 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
In this study, we aimed to provide a comprehensive description of cancer-associated KRAB-ZNFs using publicly available The Cancer Genome Atlas pan-cancer datasets.
|
30444046 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
A protein central to ALS is the nuclear RNA/DNA-binding protein, TDP-43.
|
30157956 |
2018 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
These findings have highlighted the need for further characterization of ZnF proteins, which can reveal the functions of this large gene class in normal cell function and human diseases, including those involving genome instability such as aging and cancer.
|
29370947 |
2018 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
These findings have highlighted the need for further characterization of ZnF proteins, which can reveal the functions of this large gene class in normal cell function and human diseases, including those involving genome instability such as aging and cancer.
|
29370947 |
2018 |
|
Amyotrophic Lateral Sclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Withania somnifera Reverses Transactive Response DNA Binding Protein 43 Proteinopathy in a Mouse Model of Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration.
|
27928708 |
2017 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Zinc finger (ZNF) proteins, a diverse family of proteins, have multiple biological functions in cancer.
|
27655485 |
2017 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
As a typical member of KRAB-ZNFs, dysregulation of ZNF300 contributes to multiple pathologies such as leukemia and cancer.
|
28670441 |
2017 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
As a typical member of KRAB-ZNFs, dysregulation of ZNF300 contributes to multiple pathologies such as leukemia and cancer.
|
28670441 |
2017 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Zinc finger (ZNF) proteins, a diverse family of proteins, have multiple biological functions in cancer.
|
27655485 |
2017 |
|
Gastrointestinal Stromal Tumors
|
0.030 |
Biomarker
|
group |
BEFREE |
These screens identified seventeen "IM sensitizing genes" in GIST cells (sensitization index (SI) <0.85 ratio of drug/vehicle) with a false discovery rate (FDR) <15%, including twelve ZNF genes, the majority of which are located within the HSA19p12-13.1 locus.
|
23372733 |
2013 |
|
Gastrointestinal Stromal Tumors
|
0.030 |
AlteredExpression
|
group |
BEFREE |
GSTT1 copy number gain and ZNF overexpression are predictors of poor response to imatinib in gastrointestinal stromal tumors.
|
24124608 |
2013 |
|
Gastrointestinal Stromal Tumors
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Importantly, 10 KRAB-ZNF genes mapped to a single locus on chromosome 19p, and a subset predicted likely response to imatinib mesylate-based therapy in a naïve panel of GIST.
|
19671739 |
2009 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Inhibitor of DNA-Binding Protein 4 Suppresses Cancer Metastasis through the Regulation of Epithelial Mesenchymal Transition in Lung Adenocarcinoma.
|
31847356 |
2019 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
By inhibiting the proliferation of myeloma cells, miR-186 gene and ZNF protein may be used as tumor suppressors in the treatment of myeloma.
|
31165610 |
2019 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Finally, by analyzing the clinicopathological data for breast and lung cancers, we demonstrated that the expression of cancer-associated KRAB-ZNFs correlates with patient survival, tumor histology, and molecular subtyping.
|
30444046 |
2019 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Together, our results show that KAP1-mediated stimulation of multiple KRAB-ZNF contributes to the growth and metastasis of breast cancer.
|
25421577 |
2015 |
|
Multiple Myeloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
By inhibiting the proliferation of myeloma cells, miR-186 gene and ZNF protein may be used as tumor suppressors in the treatment of myeloma.
|
31165610 |
2019 |