|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Conclusion: SIRT4 could exert its tumor suppressive function in HCC by inhibiting glutamine metabolism and thereby increasing the adenosine diphosphate (ADP)/AMP levels to phosphorylate AMPKα by LKB1, which blocks the mTOR signaling pathway.
|
30552782 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SIRT4 acts as a tumour suppressor of tumour growth by regulating cell metabolism, inflammation, and anti-tumourigenesis.
|
31744516 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, several studies have suggested that SIRT4 may function as either a tumor oncogene or a tumor suppressor gene.
|
30992675 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent studies demonstrated that SIRT4 can regulate glutamine metabolism and thus act as a tumor suppressor.
|
30745932 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SIRT4 has also been identified as a mitochondrial-localized tumor suppressor.
|
30666234 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, our findings show that SIRT4 serves as a tumor suppressor in GC and might act as a novel biomarker and a therapeutic target of GC.
|
30022839 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SIRT4 exhibits a tumor suppressor function in human NB and inhibits mitochondrial metabolism and SIRT1 expression in tumor cells, thereby reducing the energy metabolism of tumor cells.
|
30519106 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Subsequently, we evaluated the role of SIRT4 with oncogenic or tumor-suppressive activity in cancer, which may provide insight in identifying the underlying mechanism of action of SIRT4 in cancer.
|
29928130 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, several studies have suggested that SIRT4 not only regulates glutamine metabolism, but also serves as a tumor suppressor.
|
28582846 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Low levels of SIRT4 expression was correlated with tumor node metastasis (TNM) stage, histological type of tumor (adenocarcinoma), lymph nodal status, Ki-67 (proliferation index) and poor overall survival.
|
27941873 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A family of orthologues of yeast silent information regulator 3 (SIRT3), 4 (SIRT4) and mitochondrial tumor suppressor 1 (MTUS1) are important mitochondrial tumor suppressor genes which play an important role in the progression of multiple cancers.
|
26785117 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, Sirtuin family of genes shows differential expressions in breast cancer tissues and cells and SIRT1 and SIRT4 seem to play key tumor suppressor roles in breast cancer development.
|
27080717 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent studies indicate that SIRT4 acts as a tumor suppressor by regulating glutamine metabolism.
|
26986234 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SIRT4 has a tumour-suppressive function and may serve as a novel therapeutic target in colorectal cancer.
|
26086877 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, the mitochondrial sirtuin SIRT4 has been reported to function as a tumor suppressor by regulating glutamine metabolism, suggesting that it might have therapeutic potential for treating glutamine-dependent cancers.
|
24368766 |
2014 |