SIRT1, sirtuin 1, 23411

N. diseases: 675; N. variants: 21
Disease: Adrenoleukodystrophy ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0162309
Disease: Adrenoleukodystrophy
Adrenoleukodystrophy 		0.030 Biomarker disease BEFREE The dysregulation of SIRT1-DEPTOR-mTORC1 signaling is a critical determinant of ALD pathology; targeting SIRT1 and DEPTOR and selectively inhibiting mTORC1-S6K1 signaling may have therapeutic potential for treating ALD in humans.(Hepatology 2018). 29457836 2018
CUI: C0162309
Disease: Adrenoleukodystrophy
Adrenoleukodystrophy 		0.030 Biomarker disease BEFREE Activation of SIRT1 may serve as a novel target for the treatment of ALD. 27871879 2017
CUI: C0162309
Disease: Adrenoleukodystrophy
Adrenoleukodystrophy 		0.030 Biomarker disease BEFREE These results indicate that the reactivation of SIRT1 may be a valuable strategy to treat X-ALD and other axonopathies in which the control of redox and energetic homeostasis is impaired. 25822341 2015