SIRT1, sirtuin 1, 23411

N. diseases: 675; N. variants: 21
Disease: Vascular calcification ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.020 Biomarker phenotype BEFREE These findings demonstrate the key role that SIRT1 plays in preventing calcification in a diabetic environment, through the inhibition of RUNX2 and senescence pathways, suggesting a downregulation of SIRT1 may be responsible for perpetuating vascular calcification in diabetes. 30696833 2019
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.020 GeneticVariation phenotype BEFREE Furthermore, unlike in Mir34a<sup>+/+</sup> SMC, the known VC inhibitors SIRT1 and Axl (AXL receptor tyrosine kinase) were only partially downregulated in calcifying Mir34a<sup>-/-</sup> SMC. 30026277 2018