Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Berberine chloride ameliorated PI3K/Akt-p/SIRT-1/PTEN signaling pathway in insulin resistance syndrome induced in rats.
|
31512260 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results indicate that activation of the miR-34a/SIRT1:AMPK pathway leads to mitochondrial dynamics dysfunction in skeletal muscle of human and experimental NAFLD, representing an appealing prospective target in metabolic syndrome.
|
31139863 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Finally, we demonstrated that EF-sir2 could significantly improve the metabolic index of mammalian cells through insulin resistanced model in vitro and metabolic syndrome rat model in vivo.
|
30512225 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
The NAD<sup>+</sup>-dependent deacetylase SIRT1, which is associated with the improvement of metabolic syndromes, such as type 2 diabetes, is a well-known longevity-related gene.
|
29402742 |
2018 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
SIRT1, for example, protects against a decline in vascular endothelial function, metabolic syndrome, ischemia-reperfusion injury, obesity, and cardiomyopathy, and SIRT3 is protective against dyslipidemia and ischemia-reperfusion injury.
|
30355082 |
2018 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings indicate that IGFBP-2 might be a new target of metformin action in diabetes and the metformin-AMPK-Sirt1-PPARα-IGFBP-2 network may provide a novel pathway that could be applied to ameliorate metabolic syndromes by controlling IGF-1 bioavailability.
|
27009398 |
2016 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
RGD |
Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity.
|
25356430 |
2014 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results indicate that glutathione adducts on specific SirT1 thiols may be responsible for dysfunctional SirT1 associated with liver disease in metabolic syndrome.
|
24451382 |
2014 |
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
HuR expression and binding to SIRT1 were also analysed ex vivo in peripheral blood mononuclear cells (PBMCs) of subjects with and without the metabolic syndrome (MS), by immunoprecipitation (IP) of the ribonucleoprotein (RNP) complex.
|
24702436 |
2014 |
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Age-related MS and diabetes are also causally associated with suppressed SIRT1 partly due to oxidant glycotoxins [advanced glycation end products (AGEs)].
|
24567379 |
2014 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
SIRT1 in metabolic syndrome: where to target matters.
|
22939883 |
2012 |
Metabolic Syndrome X
|
0.600 |
Therapeutic
|
disease |
RGD |
To determine the effects of food restriction (FR) on the expression of Sirt1 and its down-stream factors related to lipid and glucose metabolism in obese and hypertensive rats (SHRSP/IDmcr-fa), as a model of human metabolic syndrome.
|
21514307 |
2011 |
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In vivo, insulin resistance and metabolic syndrome were associated with low PBMC SIRT1 gene and protein expression.
|
20068143 |
2010 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
CTD_human |
In vivo, insulin resistance and metabolic syndrome were associated with low PBMC SIRT1 gene and protein expression.
|
20068143 |
2010 |
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Nominally significant associations were also observed between T2D and the SIRT1 rs3758391 SNP and MS and the HHEX rs5015480 polymorphism.
|
20503258 |
2010 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings suggest that SIRT1 might be a new therapeutic target for the prevention of disease related to insulin resistance, such as metabolic syndrome and diabetes mellitus, although direct evidence from clinical studies in humans is needed to prove this possibility.
|
19455179 |
2009 |