|
Tumor-Associated Vasculature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Prostate-specific membrane antigen (PSMA) is expressed on the endothelial cells of tumor-associated neovasculature of various nonprostatic benign and malignant neoplasms.
|
31348086 |
2020 |
|
Tumor-Associated Vasculature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PSMA (prostate-specific membrane antigen) is specifically expressed in prostate cancer and the neovasculature of certain cancer types, thus is considered to be an ideal target for cancer therapy.
|
31048359 |
2019 |
|
Tumor-Associated Vasculature
|
0.100 |
Biomarker
|
disease |
BEFREE |
PSMA, a marker of neovasculature formation expressed by DTC, contributes in the prediction of tumor aggressiveness and patient outcome.
|
31617002 |
2019 |
|
Tumor-Associated Vasculature
|
0.100 |
Biomarker
|
disease |
BEFREE |
Despite its name, prostate-specific membrane antigen (PSMA) has been shown using immunohistochemistry (IHC) to also be over-expressed in the tumor neovasculature of a wide variety of solid tumors other than prostate carcinoma.
|
31581638 |
2019 |
|
Tumor-Associated Vasculature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Prostate-specific membrane antigen is also expressed in the endothelium of neovasculature of various solid malignancies possibly due to tumor-associated angiogenic factors and endothelial cell sprouting.
|
30985434 |
2019 |
|
Tumor-Associated Vasculature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Among the 103 cases, 27 cases (26%) showed PSMA expression in more than 50% of tumor-associated vasculature, 49 cases (48%) showed PSMA expression in less than 50% of vasculature, and 27 cases (26%) did not have detectable PSMA expression.
|
31136358 |
2019 |
|
Tumor-Associated Vasculature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the expression of PSMA on the tumor neovasculature of many nonprostate malignancies has enabled a burgeoning subfield concentrated on delineating the potential utility of PSMA-targeted PET agents for imaging other cancers.
|
30691373 |
2019 |
|
Tumor-Associated Vasculature
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prostate-specific membrane antigen (PSMA) is a biomarker that is overexpressed on prostate cancer, and it is also present on the neovasculature within many non-prostate solid tumors.
|
31075200 |
2019 |
|
Tumor-Associated Vasculature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The majority of clear cell RCCs (ccRCC), the most malignant RCC subtype, express PSMA on tumor-associated neovasculature.
|
31605269 |
2019 |
|
Tumor-Associated Vasculature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, PSMA expression is also noted in various benign and malignant nonprostatic neoplasms in the endothelial cells of tumor-associated neovasculature.
|
30516685 |
2019 |
|
Tumor-Associated Vasculature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Beyond the enhanced accumulation of PSMA on prostate cancer cells, PSMA expression is also found on the molecular surface or in the tumor-associated neovasculature of various tumor tissues including sarcomas of the soft tissue 2.
|
31140181 |
2019 |
|
Tumor-Associated Vasculature
|
0.100 |
Biomarker
|
disease |
BEFREE |
PSMA and CD34 immunostaining were noted in the neovasculature of IVC tumour and renal tumour tissue.
|
31236332 |
2019 |
|
Tumor-Associated Vasculature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Among the 103 cases, 27 cases (26%) showed PSMA expression in more than 50% of tumor-associated vasculature, 49 cases (48%) showed PSMA expression in less than 50% of vasculature, and 27 cases (26%) did not have detectable PSMA expression.
|
31116141 |
2019 |
|
Tumor-Associated Vasculature
|
0.100 |
Biomarker
|
disease |
BEFREE |
PSMA is also overexpressed in the neovasculature of other tumours including renal cell carcinoma (RCC), suggesting there may be a role for the use of <sup>68</sup>Ga-PSMA PET/CT.
|
31332498 |
2019 |
|
Tumor-Associated Vasculature
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ga-PSMA binds to PSMA-expressing prostate cancer cells, but it can also bind to the neovasculature of various solid tumors, as well as to some benign lesions.
|
31058693 |
2019 |
|
Tumor-Associated Vasculature
|
0.100 |
Biomarker
|
disease |
BEFREE |
Despite its nomenclature, PSMA has also been found to be expressed in the neovasculature of non-prostate cancers such as renal cell carcinoma (RCC) and hence PSMA PET/CT imaging has been proposed as an alternative staging modality.
|
30617728 |
2019 |
|
Tumor-Associated Vasculature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Despite its name, PSMA is also expressed, to varying degrees, in the neovasculature of a wide variety of nonprostate cancers; indeed, the pathology literature is replete with promising immunohistochemistry findings.
|
29545375 |
2018 |
|
Tumor-Associated Vasculature
|
0.100 |
Biomarker
|
disease |
BEFREE |
We give special prominence to the importance of PSMA as a target for imaging and therapy in prostate cancer and its underdeveloped role for imaging and targeting the neovasculature of tumors other than prostate cancer.
|
29674422 |
2018 |
|
Tumor-Associated Vasculature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Prostate-specific membrane antigen is expressed in the neovasculature of several solid tumors.
|
30300203 |
2018 |
|
Tumor-Associated Vasculature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, PSMA expression levels in the neovasculature of poorly and undifferentiated thyroid cancers were significantly higher compared to differentiated thyroid tumors (<i>p</i> = 0.021).
|
29515776 |
2018 |
|
Tumor-Associated Vasculature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer and within the neovasculature of other solid tumors.
|
29025989 |
2018 |
|
Tumor-Associated Vasculature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Prostate-specific membrane antigen (PSMA) overexpression is not restricted to prostate cancer, but it has also been demonstrated in gliomas, lung cancer, and in tumor neovasculature.
|
29894335 |
2018 |
|
Tumor-Associated Vasculature
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the potential of PSMA for the evaluation of the tumor neovasculature of various brain tumors and the possibility of detecting PSMA expression in brain tumors using PET imaging with <sup>89</sup>Zr-Df-IAB2M (anti-PSMA minibody).
|
29524126 |
2018 |
|
Tumor-Associated Vasculature
|
0.100 |
Biomarker
|
disease |
BEFREE |
Glutamate carboxypeptidase II (GCPII) is a membrane protease overexpressed by prostate cancer cells and detected in the neovasculature of most solid tumors.
|
29389139 |
2018 |
|
Tumor-Associated Vasculature
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We conclude that PSMA is expressed in the neovasculature of a subset of soft tissue tumors to a variable extent.
|
28002805 |
2017 |