|
Huntington Disease
|
0.200 |
Biomarker
|
disease |
RGD |
Basal ganglia lesions in the rat: effects on quinolinic acid metabolism.
|
2527078 |
1989 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we show that a bottleneck enzyme in de novo biosynthesis, quinolinate phosphoribosyltransferase (QPRT), defends renal NAD<sup>+</sup> and mediates resistance to acute kidney injury (AKI).
|
30127395 |
2018 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
QPRT function was inhibited in SH-SY5Y neuroblastoma cells using (i) siRNA knockdown (KD), (ii) chemical mimicking of loss of QPRT, and (iii) complete CRISPR/Cas9-mediated knock out (KO).
|
30443311 |
2018 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
QPRT function was inhibited in SH-SY5Y neuroblastoma cells using (i) siRNA knockdown (KD), (ii) chemical mimicking of loss of QPRT, and (iii) complete CRISPR/Cas9-mediated knock out (KO).
|
30443311 |
2018 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
QPRT function was inhibited in SH-SY5Y neuroblastoma cells using (i) siRNA knockdown (KD), (ii) chemical mimicking of loss of QPRT, and (iii) complete CRISPR/Cas9-mediated knock out (KO).
|
30443311 |
2018 |
|
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection.
|
28724915 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
When investigating possible gene expression network partners of WT1 in a large acute myeloid leukemia (AML) patient cohort, one of the genes with the highest correlation to WT1 was quinolinate phosphoribosyltransferase (QPRT), a key enzyme in the de novo nicotinamide adenine dinucleotide (NAD+) synthesis pathway.
|
27889611 |
2017 |
|
Nephroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells.
|
27889611 |
2017 |
|
Childhood Kidney Wilms Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells.
|
27889611 |
2017 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
QPRT is also essential for maintaining the homeostasis of quinolinic acid in the brain, a possible neurotoxin causing various neurodegenerative diseases.
|
26805589 |
2016 |
|
Malignant Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on our comparison of human QPRT structures in the apo and complex forms, we propose a drug design strategy targeting malignant glioma.
|
26805589 |
2016 |
|
Thyroid Nodule
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consequently, QPRT is a potential new marker for the immunohistochemical screening of follicular thyroid nodules.
|
19321014 |
2009 |
|
Thyroid Gland Follicular Adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In gene expression analysis QPRT was detected as differently expressed between follicular thyroid adenoma and follicular thyroid carcinoma.
|
19321014 |
2009 |
|
Follicular adenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
QPRT protein could be detected by immunohistochemistry in 65% of follicular thyroid carcinomas including minimal invasive variant and only 22% of follicular adenomas.
|
19321014 |
2009 |
|
Follicular thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
QPRT protein could be detected by immunohistochemistry in 65% of follicular thyroid carcinomas including minimal invasive variant and only 22% of follicular adenomas.
|
19321014 |
2009 |