BRD4, bromodomain containing 4, 23476

N. diseases: 335; N. variants: 6
Disease: Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.050 GeneticVariation group BEFREE Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628. 26976114 2016
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.050 GeneticVariation group BEFREE After partial parotidectomy, the diagnosis of a NMC was made based on the presence of t(15;19)(q14;p13.1) and BRD4/NUT fusion gene demonstrated by fluorescence in situ hybridization (FISH). 26027633 2016
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.050 AlteredExpression group BEFREE These studies identify this stem cell marker as a novel BRD4-NUT target that supports the highly aggressive transforming activity of t(15;19) carcinomas. 24736545 2014
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.050 Biomarker group BEFREE Brd4 is essential for cellular growth and has been implicated in cell cycle control, DNA replication, and gene rearrangement found in t(15;19)-associated carcinomas. 17329240 2007
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.050 GeneticVariation group BEFREE Four published carcinomas with BRD4 and NUT rearrangements were also evaluated. 15483023 2004