BRD4, bromodomain containing 4, 23476

N. diseases: 335; N. variants: 6
Disease: Pancreatic carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.040 Biomarker disease BEFREE Strikingly, we showed that HAT1 transcriptionally regulated PD-L1, and this process was mainly mediated by BRD4 in pancreatic cancer. 30709380 2019
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.040 AlteredExpression disease BEFREE Taken together, our results elucidated the regulation of B7-H3 expression in pancreatic cancer and uncovered the importance of BRD4/B7-H3/TLR4 pathway. 30664982 2019
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.040 AlteredExpression disease BEFREE Furthermore, we showed that PES1 interacted with BRD4 to enhance c-Myc expression, which is the primary cause of cancer cell resistance to BET inhibitors in pancreatic cancer. 31718704 2019
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.040 AlteredExpression disease BEFREE Here we show that pancreatic cancer cells developing resistance to JQ1 demonstrate cross-resistance to I-BET151 and insensitivity to BRD4 downregulation. 25807524 2015