|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings suggest that CBX7 might be a tumor suppressor and could be a potential target in cervical cancer.
|
31709304 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Loss of CBX7 expression has been reported in several human malignant neoplasias, where it often correlates with an advanced cancer state and poor survival, proposing CBX7 as a candidate tumor-suppressor gene in cancer progression.
|
30826432 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
miR-19 functions as a tumor accelerator promoting lung cancer cell proliferation through targeting CBX7 and inhibiting its expression.
|
30584339 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest CBX7 is an important tumor suppressor that negatively modulates PTEN/Akt signaling during pancreatic tumorigenesis.
|
28030829 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CBX7, a member of the Polycomb-group proteins, plays a significant role in normal and cancerous tissues and has been defined as a tumor suppressor in thyroid, breast and pancreatic cancers.
|
28388562 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This role is supported from the development of benign and malignant neoplasias in Cbx7 null mice.
|
28259135 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, in vivo bioluminescence imaging and survival times of nude mice revealed that CBX7 behaved as a tumor suppressor in gliomas.
|
28460453 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Integration of tissue and gene ontology data prioritized miR-375 targets and identified the tumor suppressor gene CBX7, a member of Polycomb repressive complex 1, as a major miR-375 target.
|
27449098 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, these findings indicate that CBX7-mediated epigenetic induction of DKK-1 is crucial for the inhibition of breast tumorigenicity, suggesting that CBX7 could be a potential tumor suppressor in human breast cancer.
|
25351982 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The purpose of this study is to verify the tumor suppressor role of Cbx7 in human colon carcinomas (CC).
|
25881303 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Several recent studies have reported the Polycomb Repressive Complex 1 member CBX7 as a tumor-suppressor gene whose expression progressively decreases in different human carcinomas in relation with tumor grade, malignant stage and poor prognosis.
|
25595895 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We show that Atf3 is a tumor-suppressor gene inactivated in human glioblastoma multiforme together with Cbx7 and a few other candidates.
|
23680149 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggest that CBX7 is a tumor suppressor and that its loss plays a key role in the pathogenesis of cancer.
|
22214847 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The generation of knockout mice for the Cbx7 gene validates the tumor suppressor role of CBX7, whose expression is lost in several human malignancies.
|
22544325 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus.
|
20723236 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Chromobox protein homologue 7 (CBX7) is a chromobox family protein encoding a novel polycomb protein, the expression of which shows a progressive reduction, well related with the malignant grade of the thyroid neoplasias.
|
19706751 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CBX7 expression progressively decreased with malignancy grade and neoplasia stage.
|
18701502 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression levels of CBX7 inversely correlate with the progression of tumor stage and grade in urothelial carcinomas of the bladder, suggesting that downregulation of CBX7 indicates aggressive urothelial carcinoma phenotype.
|
18984978 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Chromobox 7 (CBX7) is a chromobox family protein and a component of the Polycomb repressive complex 1 (PRC1) that extends the lifespan of cultured epithelial cells and can act independently of BMI-1 to repress the INK4a/ARF tumor suppressor locus.
|
17374722 |
2007 |