|
IGA Glomerulonephritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
The molecular phenotype of endocapillary proliferation: novel therapeutic targets for IgA nephropathy.
|
25133636 |
2014 |
|
Non-Small Cell Lung Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839).
|
15496427 |
2004 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
|
29844566 |
2018 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Bivariate Genome-Wide Association Scan Identifies 6 Novel Loci Associated With Lipid Levels and Coronary Artery Disease.
|
30525989 |
2018 |
|
Coronary Artery Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Bivariate Genome-Wide Association Scan Identifies 6 Novel Loci Associated With Lipid Levels and Coronary Artery Disease.
|
30525989 |
2018 |
|
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A common variant association study reveals novel susceptibility loci for low HDL-cholesterol levels in ethnic Arabs.
|
26879886 |
2016 |
|
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
CRN2 is an actin filament binding protein involved in the regulation of various cellular processes including cell migration and invasion.
|
31677819 |
2019 |
|
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
We provide evidence that, akin to cortactin, coronin 1C is required for invadopodia formation and matrix degradation by breast cancer cells lines and for 3D collagen invasion by multicellular spheroids.
|
30065298 |
2018 |
|
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
A Gaussia luciferase reporter assay was used to determine if CORO1C is a putative YB-1 downstream target. siRNA-mediated silencing of CORO1C and down-regulation of YBX1 in CORO1C overexpressing MDA-MB-231 cells were performed to evaluate cell migration and invasion.
|
28302118 |
2017 |
|
Tumor Cell Invasion
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Silencing of CORO1C gene expression inhibited cancer cell proliferation, migration and invasion.
|
25518741 |
2015 |
|
Tumor Cell Invasion
|
0.070 |
GeneticVariation
|
phenotype |
BEFREE |
CRN2 over-expression and expression of the S463A phospho-resistant CRN2 variant increase proliferation, matrix degradation, and invasion but decrease adhesion and formation of invadopodia-like extensions in vitro.
|
23410663 |
2013 |
|
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Stable knockdown of coronin 3 by this lentiviral vector could efficiently inhibit the migration and invasion of MKN45 gastric cancer cells.
|
22974233 |
2012 |
|
Tumor Cell Invasion
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Coronin-3 knockdown glioblastoma cells exhibited reduced levels of cell proliferation, cell motility and invasion into extracellular matrix compared to control cells.
|
18189330 |
2008 |
|
Neoplasm Metastasis
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, overexpression of coronin-3 could reverse the miR-26-induced inhibition in cell growth and metastasis.
|
31595425 |
2020 |
|
Neoplasm Metastasis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
CORO1C was previously reported to promote metastasis in breast cancer and lung squamous cell carcinoma.
|
30974047 |
2019 |
|
Neoplasm Metastasis
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
CONCLUSIONS Coronin 1c protein and F-actin protein are highly expressed in breast cancer and their expression may be related to the metastasis of breast cancer cells.
|
30150608 |
2018 |
|
Neoplasm Metastasis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The association between YB-1 and coronin-1C offers a novel approach by which metastasis of breast cancer cells could be targeted and abrogated.
|
28302118 |
2017 |
|
Neoplasm Metastasis
|
0.060 |
PosttranslationalModification
|
phenotype |
BEFREE |
Further, silencing of CORO1C reduced tumor cell migration and affected the actin skeleton and cell morphology, similar to miR-206 expression, but did not reduce proliferation.
|
25074552 |
2014 |
|
Neoplasm Metastasis
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
We also demonstrated that the expression of coronin 3 was remarkably higher in lymph lode metastases than in primary gastric cancer tissues, and over-expression of coronin 3 was correlated with the increased clinical stage and lymph lode metastasis.
|
22974233 |
2012 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Coronin-3 (coronin-1C), a homotrimer F-actin-binding protein, has been reported to be important for metastasis in several types of cancers such as lung cancer, gastric cancer, and breast cancer.
|
31595425 |
2020 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Coronin-3 (coronin-1C), a homotrimer F-actin-binding protein, has been reported to be important for metastasis in several types of cancers such as lung cancer, gastric cancer, and breast cancer.
|
31595425 |
2020 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
CORO1C was previously reported to promote metastasis in breast cancer and lung squamous cell carcinoma.
|
30974047 |
2019 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
CORO1C was previously reported to promote metastasis in breast cancer and lung squamous cell carcinoma.
|
30974047 |
2019 |
|
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
CONCLUSIONS Coronin 1c protein and F-actin protein are highly expressed in breast cancer and their expression may be related to the metastasis of breast cancer cells.
|
30150608 |
2018 |
|
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
We report that expression of coronin 1C is elevated in invasive human breast cancers, correlates positively with MT1-MMP expression in relation with increased metastatic risk and is a new independent prognostic factor in breast cancer.
|
30065298 |
2018 |