PRND, prion like protein doppel, 23627

N. diseases: 27; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003467
Disease: Anxiety
Anxiety 		0.010 GeneticVariation disease BEFREE In AD patients, carrier status of the T allele of the 3'UTR (untranslated region) PRND polymorphism was associated with an increased cumulative behavioral load and an elevated risk for delusions, anxiety, agitation/aggression, apathy and irritability/emotional ability. 22453181 2012
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.010 GeneticVariation group BEFREE In AD patients, carrier status of the T allele of the 3'UTR (untranslated region) PRND polymorphism was associated with an increased cumulative behavioral load and an elevated risk for delusions, anxiety, agitation/aggression, apathy and irritability/emotional ability. 22453181 2012
CUI: C0011253
Disease: Delusions
Delusions 		0.010 GeneticVariation disease BEFREE In AD patients, carrier status of the T allele of the 3'UTR (untranslated region) PRND polymorphism was associated with an increased cumulative behavioral load and an elevated risk for delusions, anxiety, agitation/aggression, apathy and irritability/emotional ability. 22453181 2012
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 Biomarker phenotype BEFREE Prion proteins (PRNP and PRND), known mostly for its involvement in neurodegenerative spongiform encephalopathies, have been recently demonstrated to be involved in resistance to apoptosis, tumorigenesis, proliferation, and metastasis. 22147650 2012
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.010 AlteredExpression disease BEFREE PRNP and PRND are significantly over-expressed in osteosarcoma. 22147650 2012
CUI: C0085584
Disease: Encephalopathies
Encephalopathies 		0.010 Biomarker group BEFREE Prion proteins (PRNP and PRND), known mostly for its involvement in neurodegenerative spongiform encephalopathies, have been recently demonstrated to be involved in resistance to apoptosis, tumorigenesis, proliferation, and metastasis. 22147650 2012
CUI: C0085632
Disease: Apathy
Apathy 		0.010 GeneticVariation phenotype BEFREE In AD patients, carrier status of the T allele of the 3'UTR (untranslated region) PRND polymorphism was associated with an increased cumulative behavioral load and an elevated risk for delusions, anxiety, agitation/aggression, apathy and irritability/emotional ability. 22453181 2012
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.010 GeneticVariation phenotype BEFREE PRND 3'UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease. 22453181 2012
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.010 AlteredExpression disease BEFREE PRNP and PRND are significantly over-expressed in osteosarcoma. 22147650 2012
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 Biomarker phenotype BEFREE PRNP and PRND appear involved with some important genes related to tumorigenesis and apoptosis. 22147650 2012
CUI: C1270972
Disease: Mild cognitive disorder
Mild cognitive disorder 		0.010 Biomarker disease BEFREE In this research paper, our aim is to evaluate the association between the APOE, CYP46, PRNP and PRND genes and the profile of neuropsychiatric symptoms in Polish subjects with AD and mild cognitive impairment (MCI). 22453181 2012
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.010 AlteredExpression disease BEFREE PRNP and PRND are significantly over-expressed in osteosarcoma. 22147650 2012
CUI: C4285807
Disease: Behavioral and psychological symptoms of dementia
Behavioral and psychological symptoms of dementia 		0.010 GeneticVariation phenotype BEFREE In this research paper, our aim is to evaluate the association between the APOE, CYP46, PRNP and PRND genes and the profile of neuropsychiatric symptoms in Polish subjects with AD and mild cognitive impairment (MCI). 22453181 2012
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 AlteredExpression group BEFREE Extensive differences in PRND gene expression were also found within each grade of malignancy, suggesting that PRND mRNA quantitation might be useful to distinguish astrocytoma subtypes, and important in disease stratification and in the assessment of specific treatment strategies. 17390034 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 AlteredExpression group BEFREE Diagnostic value of PRND gene expression profiles in astrocytomas: relationship to tumor grades of malignancy. 17390034 2007
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.010 AlteredExpression group BEFREE Extensive differences in PRND gene expression were also found within each grade of malignancy, suggesting that PRND mRNA quantitation might be useful to distinguish astrocytoma subtypes, and important in disease stratification and in the assessment of specific treatment strategies. 17390034 2007
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.010 Biomarker group BEFREE The human PRND open reading frame has been shown to contain polymorphic codons, but research on a correlation between the PRND polymorphic sequences and neurodegenerative disorders carried out to date in different populations have shown contradictory results. 15449459 2004
CUI: C2900450
Disease: Other Creutzfeldt-Jakob disease
Other Creutzfeldt-Jakob disease 		0.010 GeneticVariation disease BEFREE To answer the question of whether there are any polymorphisms within the PrP-like protein gene (Prnd) that might cause or be involved in the development of TSEs, we investigated the complete open reading frame of the human Prnd gene from 58 patients who had died of genetic or sporadic Creutzfeldt-Jakob disease (CJD), Alzheimer's disease or other neurological disorders and from 111 controls. 11702213 2001
CUI: C0162534
Disease: Prion Diseases
Prion Diseases 		0.010 Biomarker group BEFREE The aim of this study was to investigate the possible involvement of genetic variation in the prion-like protein gene (PRND), which encodes the doppel protein (Dpl), in the aetiology of human prion diseases. 10825657 2000
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.020 Biomarker disease BEFREE Altered cellular distribution and sub-cellular sorting of doppel (Dpl) protein in human astrocytoma cell lines. 18607068 2008
CUI: C1852467
Disease: Creutzfeldt-Jakob Disease, Sporadic
Creutzfeldt-Jakob Disease, Sporadic 		0.020 Biomarker disease BEFREE Our study evaluated previous findings of the association of SNPs in the PRNP and PRND genes in the largest cohorts for association study in sCJD to date, and extends previous findings by defining for the first time the haplotypes associated with sCJD in a large population of the German CJD surveillance study. 17047093 2006
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.020 Biomarker disease BEFREE Our findings suggest that the PRND gene might be a useful molecular marker in astrocytoma progression and in tumor grade definition. 15274317 2004
CUI: C1852467
Disease: Creutzfeldt-Jakob Disease, Sporadic
Creutzfeldt-Jakob Disease, Sporadic 		0.020 GeneticVariation disease BEFREE To answer the question of whether there are any polymorphisms within the PrP-like protein gene (Prnd) that might cause or be involved in the development of TSEs, we investigated the complete open reading frame of the human Prnd gene from 58 patients who had died of genetic or sporadic Creutzfeldt-Jakob disease (CJD), Alzheimer's disease or other neurological disorders and from 111 controls. 11702213 2001
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 GeneticVariation disease BEFREE PRND 3'UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease. 22453181 2012
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.030 Biomarker disease BEFREE Altered cellular distribution and sub-cellular sorting of doppel (Dpl) protein in human astrocytoma cell lines. 18607068 2008