PRND, prion like protein doppel, 23627

N. diseases: 27; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022107
Disease: Irritable Mood
Irritable Mood 		0.300 Biomarker phenotype PSYGENET PRND 3'UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease. 22453181 2012
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 GeneticVariation disease BEFREE PRND 3'UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease. 22453181 2012
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.030 Biomarker disease BEFREE Altered cellular distribution and sub-cellular sorting of doppel (Dpl) protein in human astrocytoma cell lines. 18607068 2008
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.030 AlteredExpression disease BEFREE Diagnostic value of PRND gene expression profiles in astrocytomas: relationship to tumor grades of malignancy. 17390034 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 GeneticVariation disease BEFREE The authors present a study on the association of PRNP and PRND gene polymorphisms with the occurrence and age at onset of Alzheimer's disease (AD). 14745079 2004
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.030 Biomarker disease BEFREE Our findings suggest that the PRND gene might be a useful molecular marker in astrocytoma progression and in tumor grade definition. 15274317 2004
CUI: C0022336
Disease: Creutzfeldt-Jakob disease
Creutzfeldt-Jakob disease 		0.030 GeneticVariation disease BEFREE Polymorphisms in the prion protein gene and in the doppel gene increase susceptibility for Creutzfeldt-Jakob disease. 14970845 2004
CUI: C0004134
Disease: Ataxia
Ataxia 		0.030 Biomarker phenotype BEFREE Doppel protein has been discovered in prnp knock-out mouse lines, with overproduction of this protein in the brain causing ataxia and neurodegeneration. 12586339 2003
CUI: C0007758
Disease: Cerebellar Ataxia
Cerebellar Ataxia 		0.030 Biomarker phenotype BEFREE Doppel protein has been discovered in prnp knock-out mouse lines, with overproduction of this protein in the brain causing ataxia and neurodegeneration. 12586339 2003
CUI: C0022336
Disease: Creutzfeldt-Jakob disease
Creutzfeldt-Jakob disease 		0.030 AlteredExpression disease LHGDN Prion-like protein Doppel expression is not modified in scrapie-infected cells and in the brains of patients with Creutzfeldt-Jakob disease. 12586339 2003
CUI: C0022336
Disease: Creutzfeldt-Jakob disease
Creutzfeldt-Jakob disease 		0.030 AlteredExpression disease BEFREE Prion-like protein Doppel expression is not modified in scrapie-infected cells and in the brains of patients with Creutzfeldt-Jakob disease. 12586339 2003
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 Biomarker disease BEFREE Our study in the Spanish population argues against the hypothesis that the PRND gene is causally related to AD. 12399017 2002
CUI: C0004134
Disease: Ataxia
Ataxia 		0.030 Biomarker phenotype BEFREE These lines of Prnp0/0 mice exhibit ataxia and apoptosis of cerebellar cells, indicating that ectopic synthesis of Dpl protein is toxic to CNS neurons: this inference has now been confirmed by the construction of transgenic mice expressing Dpl under the direct control of the PrP promoter. 11716303 2001
CUI: C0004134
Disease: Ataxia
Ataxia 		0.030 Biomarker phenotype BEFREE These lines of Prnp(0/0) mice exhibit ataxia and apoptosis of cerebellar cells, indicating that ectopic synthesis of Dpl protein is toxic to central nervous system neurons: this inference has now been confirmed by the construction of transgenic mice expressing Dpl under the direct control of the PrP promoter. 11574147 2001
CUI: C0007758
Disease: Cerebellar Ataxia
Cerebellar Ataxia 		0.030 Biomarker phenotype BEFREE These lines of Prnp(0/0) mice exhibit ataxia and apoptosis of cerebellar cells, indicating that ectopic synthesis of Dpl protein is toxic to central nervous system neurons: this inference has now been confirmed by the construction of transgenic mice expressing Dpl under the direct control of the PrP promoter. 11574147 2001
CUI: C0007758
Disease: Cerebellar Ataxia
Cerebellar Ataxia 		0.030 Biomarker phenotype BEFREE These lines of Prnp0/0 mice exhibit ataxia and apoptosis of cerebellar cells, indicating that ectopic synthesis of Dpl protein is toxic to CNS neurons: this inference has now been confirmed by the construction of transgenic mice expressing Dpl under the direct control of the PrP promoter. 11716303 2001
CUI: C0022336
Disease: Creutzfeldt-Jakob disease
Creutzfeldt-Jakob disease 		0.030 GeneticVariation disease BEFREE To answer the question of whether there are any polymorphisms within the PrP-like protein gene (Prnd) that might cause or be involved in the development of TSEs, we investigated the complete open reading frame of the human Prnd gene from 58 patients who had died of genetic or sporadic Creutzfeldt-Jakob disease (CJD), Alzheimer's disease or other neurological disorders and from 111 controls. 11702213 2001
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.020 Biomarker disease BEFREE Altered cellular distribution and sub-cellular sorting of doppel (Dpl) protein in human astrocytoma cell lines. 18607068 2008
CUI: C1852467
Disease: Creutzfeldt-Jakob Disease, Sporadic
Creutzfeldt-Jakob Disease, Sporadic 		0.020 Biomarker disease BEFREE Our study evaluated previous findings of the association of SNPs in the PRNP and PRND genes in the largest cohorts for association study in sCJD to date, and extends previous findings by defining for the first time the haplotypes associated with sCJD in a large population of the German CJD surveillance study. 17047093 2006
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.020 Biomarker disease BEFREE Our findings suggest that the PRND gene might be a useful molecular marker in astrocytoma progression and in tumor grade definition. 15274317 2004
CUI: C1852467
Disease: Creutzfeldt-Jakob Disease, Sporadic
Creutzfeldt-Jakob Disease, Sporadic 		0.020 GeneticVariation disease BEFREE To answer the question of whether there are any polymorphisms within the PrP-like protein gene (Prnd) that might cause or be involved in the development of TSEs, we investigated the complete open reading frame of the human Prnd gene from 58 patients who had died of genetic or sporadic Creutzfeldt-Jakob disease (CJD), Alzheimer's disease or other neurological disorders and from 111 controls. 11702213 2001
CUI: C0003467
Disease: Anxiety
Anxiety 		0.010 GeneticVariation disease BEFREE In AD patients, carrier status of the T allele of the 3'UTR (untranslated region) PRND polymorphism was associated with an increased cumulative behavioral load and an elevated risk for delusions, anxiety, agitation/aggression, apathy and irritability/emotional ability. 22453181 2012
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.010 GeneticVariation group BEFREE In AD patients, carrier status of the T allele of the 3'UTR (untranslated region) PRND polymorphism was associated with an increased cumulative behavioral load and an elevated risk for delusions, anxiety, agitation/aggression, apathy and irritability/emotional ability. 22453181 2012
CUI: C0011253
Disease: Delusions
Delusions 		0.010 GeneticVariation disease BEFREE In AD patients, carrier status of the T allele of the 3'UTR (untranslated region) PRND polymorphism was associated with an increased cumulative behavioral load and an elevated risk for delusions, anxiety, agitation/aggression, apathy and irritability/emotional ability. 22453181 2012
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 Biomarker phenotype BEFREE Prion proteins (PRNP and PRND), known mostly for its involvement in neurodegenerative spongiform encephalopathies, have been recently demonstrated to be involved in resistance to apoptosis, tumorigenesis, proliferation, and metastasis. 22147650 2012