RAB38, RAB38, member RAS oncogene family, 23682

N. diseases: 34; N. variants: 17
Disease: Primary malignant neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 AlteredExpression group BEFREE Although the expression of <i>RAB38</i> is reportedly deregulated in several types of cancer, its role in tumor biology remains to be elucidated. 31452745 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 Biomarker group BEFREE Together, these data establish a novel targeted proteomic method for interrogating the small GTPase proteome in human cells and identify epigenetic reactivation of RAB38 as a contributing factor to metastatic transformation in melanoma.<b>Significance:</b> A novel quantitative proteomic method leads to the discovery of RAB38 as a new driver of metastasis in melanoma.<i>Cancer Res; 78(18); 5431-45.©2018 AACR</i>. 30072397 2018