|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although the SNP (rs138880) that previously has been associated with schizophrenia showed the same trend in the Japanese population, no significant association was detected between BRD1 and schizophrenia in our study.
|
19908236 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A comprehensive family-based replication study of schizophrenia genes.
|
23894747 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in the BRD1 locus show association with schizophrenia and bipolar disorder and risk alleles in the promoter region correlate with reduced BRD1 expression.
|
28095495 |
2017 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A comprehensive family-based replication study of schizophrenia genes.
|
23894747 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We recently demonstrated that mice heterozygous for an inactivated allele of the schizophrenia-associated Brd1 gene (Brd1<sup>+/</sup><sup>-</sup> mice) display behaviors reminiscent of schizophrenia, including impaired social cognition and long-term memory.
|
28341151 |
2017 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study assessed the transcriptional drive of a schizophrenia-associated BRD1 risk variant in vitro.
|
27837920 |
2017 |
|
Bipolar Disorder
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in the BRD1 locus show association with schizophrenia and bipolar disorder and risk alleles in the promoter region correlate with reduced BRD1 expression.
|
28095495 |
2017 |
|
Bipolar Disorder
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
The bromodomain containing 1 (BRD1) gene has been implicated with transcriptional regulation, brain development, and susceptibility to schizophrenia and bipolar disorder.
|
27142060 |
2016 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Platelet mean volume determination (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Cognition Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Mice heterozygous for an inactivated allele of the schizophrenia associated Brd1 gene display selective cognitive deficits with translational relevance to schizophrenia.
|
28341151 |
2017 |
|
Psychotic Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Identification of the BRD1 interaction network and its impact on mental disorder risk.
|
27142060 |
2016 |
|
Impaired cognition
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mice heterozygous for an inactivated allele of the schizophrenia associated Brd1 gene display selective cognitive deficits with translational relevance to schizophrenia.
|
28341151 |
2017 |
|
Malignant mesothelioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A mono-allelic variant of BRD1 was common to two MM cell lines with very low acetylation levels.
|
24916674 |
2015 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Although the SNP (rs138880) that previously has been associated with schizophrenia showed the same trend in the Japanese population, no significant association was detected between BRD1 and schizophrenia in our study.
|
19908236 |
2010 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
By integrative analysis of human genetic data, we find that the differentially abundant proteins in frontal cortex and hippocampus are enriched for schizophrenia risk further linking the actions of BRD1 to psychiatric disorders.
|
30590179 |
2019 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Taken together, we could conclude that BRD1 and ZBED4 might be population specific in schizophrenia and may not account for a substantial proportion of genetic risk for schizophrenia in the Asian population.
|
29794561 |
2018 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
The associations reported add further support for the implication of BRD1 with SZ and BPD susceptibility.
|
19693800 |
2010 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that BRD1 acts as a regulatory hub in a comprehensive schizophrenia risk network which plays a role in many brain regions throughout life, implicating e.g. striatum, hippocampus, and amygdala at mid-fetal stages.
|
27142060 |
2016 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
The results implicate BRD1 with SZ and BPD susceptibility and provide evidence that suggests a role for BRD1 in neurodevelopment.
|
16924267 |
2006 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
The associations reported add further support for the implication of BRD1 with SZ and BPD susceptibility.
|
19693800 |
2010 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
The results implicate BRD1 with SZ and BPD susceptibility and provide evidence that suggests a role for BRD1 in neurodevelopment.
|
16924267 |
2006 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Further immunohistochemical characterization of BRD1 a new susceptibility gene for schizophrenia and bipolar affective disorder.
|
19763615 |
2009 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Further immunohistochemical characterization of BRD1 a new susceptibility gene for schizophrenia and bipolar affective disorder.
|
19763615 |
2009 |