|
Jaundice, Obstructive
|
0.010 |
Biomarker
|
disease |
BEFREE |
Western blot or qRT-PCR analyses showed that the protein and mRNA expression levels of PERK, CHOP, and GADD34 were significantly increased both in the rat liver tissue and BRL-3A rat hepatocytes by OJ.
|
31749592 |
2019 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Moreover, ethanol suppressed cellular anti-apoptotic protein B-cell lymphoma-2 (Bcl-2) expression, increased pro-apoptotic protein Bcl-2-associated X protein (Bax) expression, induced mitochondrial Cytochrome C release, and activated the caspase 3-dependent apoptosis pathway in BRL-3A cells.
|
31161729 |
2019 |
|
Fibrosis, Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Characteristic features of liver fibrosis in 10% fructose-fed rats and EMT in 5 mM fructose-exposed BRL-3A cells with or without pterostilbene and the change of miR-34a/Sirt1/p53 and transforming growth factor-β1 (TGF-β1)/Smads signalling were examined.
|
30632134 |
2019 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibiting BRD1 could have potential beneficial effects in RA via decreasing the proliferation of SF.
|
30042400 |
2018 |
|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
KOH was considered the suitable choice for an OA solvent for BRL 3A cells in hepatic lipidosis research.
|
30212593 |
2018 |
|
Keratoconjunctivitis Sicca
|
0.010 |
Biomarker
|
disease |
BEFREE |
PPARγ, SOCS3 and its associated JAK2/STAT3 pathway were analyzed using Kuppfer cells (KCs) treatment with LPS and BRL-3A cells treatment with palmitic acid, KC-conditioned medium (KCCM), PPARγ agonist rosiglitazone (ROZ) or JAK2 inhibitor AG490 to demonstrate the role of PPARγ and SOCS3 in hepatocytes steatosis.
|
29550470 |
2018 |
|
Liver diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In conclusion, Patrinia may significantly reduce apoptosis of BRL‑3A induced by LPS via the TLR4/PI3K/AKT/GSK3β and TLR4/P38/JNK signaling pathways, providing evidence for its potential use in liver disease therapy.
|
29363726 |
2018 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
FDU-DB-NO<sub>2</sub> showed high cytotoxicity against hypoxic MCF-7 and MCG-803 cell lines and no cytotoxicity against normoxic BRL-3A cells and exhibited effective inhibition on tumor growth of MCF-7-cell-inoculated xenograft nude mice.
|
30192132 |
2018 |
|
Overactive Bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The relaxant effect of BRL 37344 was enhanced by rolipram but not by tadalafil, suggesting that PDE<sub>4</sub> inhibition, especially when associated with ß<sub>3</sub>-adrenoceptor stimulation, could represent a potential treatment for overactive bladder.
|
29913125 |
2018 |
|
Cocaine withdrawal
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, we found the enrichment of Brd1 messenger RNA in rats self-administering cocaine that lasted until extinction training during cocaine withdrawal with concomitant increased acetylation of H3K9 and H4K8.
|
28393332 |
2017 |
|
Cognition Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Mice heterozygous for an inactivated allele of the schizophrenia associated Brd1 gene display selective cognitive deficits with translational relevance to schizophrenia.
|
28341151 |
2017 |
|
Impaired cognition
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mice heterozygous for an inactivated allele of the schizophrenia associated Brd1 gene display selective cognitive deficits with translational relevance to schizophrenia.
|
28341151 |
2017 |
|
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
CL 316243 or ritodrine abolished the relaxation, whereas BRL 37344 increased the uterine contractility in ovarian cancer.
|
27838886 |
2017 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
CL 316243 or ritodrine abolished the relaxation, whereas BRL 37344 increased the uterine contractility in ovarian cancer.
|
27838886 |
2017 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
CL 316243 or ritodrine abolished the relaxation, whereas BRL 37344 increased the uterine contractility in ovarian cancer.
|
27838886 |
2017 |
|
Psychotic Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Identification of the BRD1 interaction network and its impact on mental disorder risk.
|
27142060 |
2016 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, CAFs exposed to BRL showed a decreased expression of CXCR4, a reduced motility and invasion along with a phenotype characterized by an altered morphology.
|
27556298 |
2016 |
|
Malignant mesothelioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A mono-allelic variant of BRD1 was common to two MM cell lines with very low acetylation levels.
|
24916674 |
2015 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of β3-AR in myocardial tissues continued to increase after the 9(th) week (p<0.05), and the expression of both β3-AR mRNA and protein in the BRL group [HF group with BRL37344 (4-[-[2-hydroxy-(3-chlorophenyl)ethyl-amino] phenoxyacetic acid) (a β3-AR agonist) injection] was positively correlated with BRL37344 when compared with non-BRL group (HF group without BRL37344 injection) (p<0.05).
|
23861938 |
2013 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of β3-AR in myocardial tissues continued to increase after the 9(th) week (p<0.05), and the expression of both β3-AR mRNA and protein in the BRL group [HF group with BRL37344 (4-[-[2-hydroxy-(3-chlorophenyl)ethyl-amino] phenoxyacetic acid) (a β3-AR agonist) injection] was positively correlated with BRL37344 when compared with non-BRL group (HF group without BRL37344 injection) (p<0.05).
|
23861938 |
2013 |
|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
In order to reduce cytotoxicity while maintain or even enhance transfecion efficiency, we modified PEI-Bu with poly(ethylene glycol) (PEG) to obtain PEG-Bu, and used it to delivery a theraputic short hairpin RNA (shRNA) targeting angiotensinogen (AGT) to normal rat liver cells (BRL-3A), which was a key target for the treatment of hypertension.
|
23894329 |
2013 |
|
Anemia, severe
|
0.010 |
Biomarker
|
disease |
BEFREE |
Brd1-deficient embryos showed severe anemia because of impaired fetal liver erythropoiesis.
|
21753189 |
2011 |
|
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Elevated levels were also found in the normal rat liver-derived lines BRL-3A and clone 9 and the H4IIE rat hepatoma, but not in the HTC, MH1C1, and MH7777 rat hepatomas.
|
2722973 |
1989 |
|
Rhabdomyosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The 34 kilodalton insulin-like growth factor binding proteins in human cerebrospinal fluid and the A673 rhabdomyosarcoma cell line are human homologues of the rat BRL-3A binding protein.
|
2476983 |
1989 |
|
Childhood Rhabdomyosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The 34 kilodalton insulin-like growth factor binding proteins in human cerebrospinal fluid and the A673 rhabdomyosarcoma cell line are human homologues of the rat BRL-3A binding protein.
|
2476983 |
1989 |