PANX1, pannexin 1, 24145

N. diseases: 107; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001364
Disease: Massive Hepatic Necrosis
Massive Hepatic Necrosis 		0.300 Biomarker phenotype CTD_human Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. 29246445 2018
CUI: C0019193
Disease: Hepatitis, Toxic
Hepatitis, Toxic 		0.300 Biomarker disease CTD_human Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. 29246445 2018
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.300 Biomarker disease CTD_human Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. 29246445 2018
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.300 Biomarker phenotype CTD_human Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. 29246445 2018
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced 		0.300 Biomarker disease CTD_human Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. 29246445 2018
CUI: C3658290
Disease: Drug-Induced Acute Liver Injury
Drug-Induced Acute Liver Injury 		0.300 Biomarker disease CTD_human Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. 29246445 2018
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker disease CTD_human Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. 29246445 2018
CUI: C4279912
Disease: Chemically-Induced Liver Toxicity
Chemically-Induced Liver Toxicity 		0.300 Biomarker disease CTD_human Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. 29246445 2018
CUI: C0085548
Disease: Autosomal Recessive Polycystic Kidney Disease
Autosomal Recessive Polycystic Kidney Disease 		0.200 Biomarker disease RGD Knockout of 31630543 2019
CUI: C0020676
Disease: Hypothyroidism
Hypothyroidism 		0.100 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0201836
Disease: Alanine aminotransferase measurement
Alanine aminotransferase measurement 		0.100 GeneticVariation phenotype GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
CUI: C0201899
Disease: Aspartate aminotransferase measurement
Aspartate aminotransferase measurement 		0.100 GeneticVariation phenotype GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
CUI: C1883008
Disease: Serum Alanine Aminotransferase Measurement
Serum Alanine Aminotransferase Measurement 		0.100 GeneticVariation phenotype GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
CUI: C0021361
Disease: Female infertility
Female infertility 		0.100 Biomarker phenotype HPO
CUI: C0036572
Disease: Seizures
Seizures 		0.050 Biomarker phenotype BEFREE We here show that targeted deletion of Panx1 in astrocytes or neurons has opposing effects on acute seizures induced by kainic acid. 30862176 2020
CUI: C0036572
Disease: Seizures
Seizures 		0.050 AlteredExpression phenotype BEFREE Pannexin-1 (Panx1) expression is raised in several animal seizure models and in resected human epileptic brain tissue, suggesting relevance to epilepsy. 28886985 2019
CUI: C0036572
Disease: Seizures
Seizures 		0.050 Biomarker phenotype BEFREE Although there are only few studies implicating Panx1 in seizures, they are illustrative of the dual role that Panx1 has on neuronal excitability. 28284836 2019
CUI: C0036572
Disease: Seizures
Seizures 		0.050 AlteredExpression phenotype BEFREE Importantly, the protein levels of Panx1 positively correlated with the frequency of seizures. 28036289 2017
CUI: C0036572
Disease: Seizures
Seizures 		0.050 AlteredExpression phenotype BEFREE Finally there is recent evidence for Cx43 hemichannels and Panx1 channels in glial membranes which could play a role in brain damage and seizure activity. 22796594 2012
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 Biomarker phenotype BEFREE The effects of Panx1 on HCC cell metastasis and invasion were observed by transwell. 31737105 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.040 AlteredExpression phenotype BEFREE Overexpression of Panx1 promoted invasion and migration of HCC cells through modulation of EMT in vitro and in vivo. 31737105 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.040 Biomarker phenotype BEFREE Overall, increased Panx-1 promotes migration and invasion in testicular cancer cells, and the effect is probably be related with ERK1/2 kinase activity. 31202174 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.040 Biomarker phenotype BEFREE Our results indicate that opening of Panx1 channels are required for <i>T. cruzi</i> invasion in cardiac myocytes, and we propose that targeting Panx1 channel could provide new potential therapeutic approaches to treat Chagas disease. 29141748 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.040 Biomarker phenotype BEFREE Here we show, using primary human dermal lymphatic endothelial cells (HDLECs), pharmacological tools (probenecid, Brilliant Blue FCF, mimetic peptides [<sup>10</sup>Panx]) and siRNA-mediated knockdown that Pannexin-1 is necessary for capillary tube formation on Matrigel and for VEGF-C-induced invasion. 29882918 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 Biomarker phenotype BEFREE Pannexin 1 (PANX1) subunits form oligomeric plasma membrane channels that mediate nucleotide release for purinergic signalling, which is involved in diverse physiological processes such as apoptosis, inflammation, blood pressure regulation, and cancer progression and metastasis. 28134257 2017