ALOX15, arachidonate 15-lipoxygenase, 246

N. diseases: 205; N. variants: 5
Disease: Congestive heart failure ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.230 Biomarker disease BEFREE The exact roles of ALOX15 and 15-HETE in the pathogenesis of heart failure are however unknown. 30138423 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.230 Biomarker disease BEFREE Cardiac 12/15-lipoxygenase (12/15-LO) was reported to be markedly up-regulated and involved in the development of heart failure. 28506553 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.230 AlteredExpression disease BEFREE To determine whether increased expression of 12/15-LOX causes heart failure, we established transgenic mice that overexpressed 12/15-LOX in cardiomyocytes. 19546247 2009
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.230 Biomarker disease RGD In CHF hearts, the expression of the muscarinic m4 (Chrm4) and nicotinic alpha4 (Chrna4) acetylcholin receptors, the ATP receptor P2rx4, nerve growth factor receptor (Ngfr), discoidin domain receptor 1 (Ddr1), neuronal pentraxin receptor (Nptxr), peripheral myelin protein Pmp-22, leukocyte type 12-lipoxygenase (Alox15), cytochrome P450 4F5 (Cyp4F5) and cardiac Kcne1 were all increased (range 1.6-6.0-fold, P < 0.01 for all genes). 16497176 2006