MTOR, mechanistic target of rapamycin kinase, 2475

N. diseases: 960; N. variants: 48
Disease: Caffeine related disorders ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0236734
Disease: Caffeine related disorders
Caffeine related disorders 		0.040 Biomarker group BEFREE These results show that the methylxanthine derivatives (caffeine and theophylline) effectively induce gastric cancer cell apoptosis and autophagy by PTEN activation and PI3K/Akt/mTOR pathway suppression and strongly support the use of methylxanthine derivatives as potential anticancer therapeutics. 30875347 2019
CUI: C0236734
Disease: Caffeine related disorders
Caffeine related disorders 		0.040 Biomarker group BEFREE We found that caffeine inhibits phosphatidylinositol 3-kinase (PI3K) and mechanistic target of rapamycin complex 2 (mTORC2). 30879206 2019
CUI: C0236734
Disease: Caffeine related disorders
Caffeine related disorders 		0.040 PosttranslationalModification group BEFREE We found that caffeine administration to mice did not significantly enhance the phosphorylation of AMPK or inhibit signaling proteins downstream of mTOR (p70S6k, S6, or 4EBP1) or protein synthesis after a bout of electrically stimulated contractions. 28177708 2017
CUI: C0236734
Disease: Caffeine related disorders
Caffeine related disorders 		0.040 Biomarker group BEFREE Caffeine only inhibited the mTOR pathway in MCF-7 cells. 28569556 2017