FRZB, frizzled related protein, 2487

N. diseases: 89; N. variants: 8
Disease: Kashin-Beck Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2745963
Disease: Kashin-Beck Disease
Kashin-Beck Disease 		0.020 AlteredExpression disease BEFREE Among the proteins involved in the Wnt/β-catenin signaling pathway, WNT-3A, FZD1, SOX9, and β-catenin were up-regulated, while FRZB was down-regulated in KBD cartilage. 29042209 2017
CUI: C2745963
Disease: Kashin-Beck Disease
Kashin-Beck Disease 		0.020 GeneticVariation disease BEFREE These finding suggested that rs7775 in the FRZB gene may increase susceptibility to KBD, while rs7033979 in the ASPN gene may play a protective role in susceptibility to KBD in Tibetans. 28651521 2017