FUT2, fucosyltransferase 2, 2524

N. diseases: 126; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2674252
Disease: VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1
VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1 		0.400 GeneticVariation phenotype CLINVAR
CUI: C2674252
Disease: VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1
VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1 		0.400 Biomarker phenotype CTD_human
CUI: C2674252
Disease: VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1
VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1 		0.400 CausalMutation phenotype CLINVAR Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency. 8755920 1996
CUI: C2674252
Disease: VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1
VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1 		0.400 CausalMutation phenotype CLINVAR A second nonsecretor allele of the blood group alpha(1,2)fucosyl-transferase gene (FUT2). 8928486 1996
CUI: C0034494
Disease: Rabies (disorder)
Rabies (disorder) 		0.010 Biomarker disease BEFREE Antibodies to the E2 region were sought for by ELISA using the following antigens: a full length E2 protein expressed in insect cells using a baculovirus vector and extracted under denaturing conditions (dE2), and a C-terminal truncated soluble E2 (sE2) protein (a.a. 390-683), also expressed with a baculovirus vector, containing a signal peptide of rabies virus G protein which allows its secretion into the culture supernatant. 8986942 1997
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.010 AlteredExpression disease BEFREE We have transfected a poorly tumorigenic rat colon carcinoma cell line with the human H blood group alpha(1-2)fucosyltransferase cDNA. 9134429 1997
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon 		0.010 Biomarker disease BEFREE Beta-1,3-galactosyltransferase and alpha-1,2-fucosyltransferase involved in the biosynthesis of type-1-chain carbohydrate antigens in human colon adenocarcinoma cell lines. 9760191 1998
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.010 GeneticVariation disease BEFREE IL1 beta, IL10 and FUT-2 polymorphisms were not associated with tuberculosis. 10645445 1998
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.010 GeneticVariation group BEFREE Modification of cell surface carbohydrates at mucosal surfaces determined by the FUT2 gene may underlie the protective association against heterosexual HIV infection. 10669366 2000
CUI: C0276501
Disease: Human immunodeficiency virus II infection
Human immunodeficiency virus II infection 		0.010 GeneticVariation disease BEFREE Among Senegalese commercial sex workers, absence of FUT2 (nonsecretor genotype) was associated with reduced risk of human immunodeficiency virus (HIV) type 1 infection (odds ratio [OR] adjusted for cervical and vaginal infection, 0.18; 95% confidence interval [CI], 0.04-0.90) and HIV-2 infection (adjusted OR, 0.43; 95% CI, 0.13-1.39), although the latter was not statistically significant. 10669366 2000
CUI: C0854094
Disease: HIV-2 infection
HIV-2 infection 		0.010 GeneticVariation disease BEFREE Among Senegalese commercial sex workers, absence of FUT2 (nonsecretor genotype) was associated with reduced risk of human immunodeficiency virus (HIV) type 1 infection (odds ratio [OR] adjusted for cervical and vaginal infection, 0.18; 95% confidence interval [CI], 0.04-0.90) and HIV-2 infection (adjusted OR, 0.43; 95% CI, 0.13-1.39), although the latter was not statistically significant. 10669366 2000
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.010 GeneticVariation disease BEFREE Among Senegalese commercial sex workers, absence of FUT2 (nonsecretor genotype) was associated with reduced risk of human immunodeficiency virus (HIV) type 1 infection (odds ratio [OR] adjusted for cervical and vaginal infection, 0.18; 95% confidence interval [CI], 0.04-0.90) and HIV-2 infection (adjusted OR, 0.43; 95% CI, 0.13-1.39), although the latter was not statistically significant. 10669366 2000
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.010 GeneticVariation disease BEFREE By using a single microsatellite marker at each locus, we screened the type 1 diabetes loci IDDM4, IDDM5, IDDM6, IDDM8, and IDDM10 and the fucosyltransferase-2 locus for linkage in sib pairs with GD. 10762555 2000
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.010 AlteredExpression disease BEFREE In striking contrast, the enzyme activity and the mRNA of alpha 1,2 fucosyltransferase did not reflect the difference in glycoconjugates observed between the CF and non-CF cells. 11530206 2001
CUI: C3534585
Disease: Infection caused by Norovirus
Infection caused by Norovirus 		0.370 Biomarker group CTD_human Human susceptibility and resistance to Norwalk virus infection. 12692541 2003
CUI: C0162677
Disease: Caliciviridae Infections
Caliciviridae Infections 		0.300 Biomarker group CTD_human Human susceptibility and resistance to Norwalk virus infection. 12692541 2003
CUI: C0206044
Disease: Infections, Calicivirus
Infections, Calicivirus 		0.300 Biomarker group CTD_human Human susceptibility and resistance to Norwalk virus infection. 12692541 2003
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.020 GeneticVariation group BEFREE The FUT2 susceptibility allele was fully penetrant against Norwalk virus infection as none of these individuals developed an infection after challenge, regardless of dose. 12692541 2003
CUI: C0343401
Disease: MRSA - Methicillin resistant Staphylococcus aureus infection
MRSA - Methicillin resistant Staphylococcus aureus infection 		0.010 Biomarker disease BEFREE All 14 MRSA strains shared Panton-Valentine leucocidin (PVL) and staphylococcal enterotoxin D (SED), SEI and SEJ; the smMSSA strain had only PVL. 16126781 2005
CUI: C3534585
Disease: Infection caused by Norovirus
Infection caused by Norovirus 		0.370 GeneticVariation group BEFREE In this study we show that the human secretor FUT2 gene, which codes for an alpha(1,2)-fucosyltransferase synthesizing the H-type 1 antigen in saliva and mucosa, is associated with susceptibility to norovirus infections. 16306606 2005
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.010 AlteredExpression disease BEFREE In this study we have investigated the importance of the FUT2 fucosyltransferase activity on the progress of HIV-1 infection. 16514298 2006
CUI: C3534585
Disease: Infection caused by Norovirus
Infection caused by Norovirus 		0.370 Biomarker group BEFREE Recent studies have shown that histo-blood group antigens (HBGAs) and in particular secretor status controlled by the alpha1,2fucosyltransferase FUT2 gene determine susceptibility to norovirus infections, with nonsecretors (FUT2-/-), representing 20% of Europeans, being highly resistant to symptomatic infections with major strains of norovirus. 16973373 2006
CUI: C3714514
Disease: Infection
Infection 		0.010 GeneticVariation group LHGDN Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark. 17537929 2007
CUI: C0374997
Disease: Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 		0.050 GeneticVariation disease BEFREE In vitro Hp adherence was higher in cases wild-type or heterozygous for FUT2 G428A mutation (p < 0.0001), cases staining for Ulex (p < 0.0001) and a(-)b+ and a(-)b(-) secretor phenotypes (p < 0.001). 18498114 2008
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.010 Biomarker disease BEFREE Our findings provide insight into further development of a Globo H-based vaccine and FUT1/FUT2-targeted therapy for breast cancer. 18685093 2008