|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
These are the first results indicating that the O blood group and FUT2 secretor status are protective factors against CD in Asians.
|
31260595 |
2020 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Several studies have been conducted to investigate the association of fucosyltransferase 2 gene (rs601338) variant with UC and CD, but the results were inconsistent.
|
30615603 |
2019 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In recent years, genome-wide association studies (GWAS) identified inactivating variants at the FUT2 locus to be associated with primary sclerosing cholangitis (PSC), Crohn's disease (CD), and biochemical markers of biliary damage.
|
24828903 |
2015 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Fine-mapping of the first locus pinpointed the FUT2 gene, which encodes a fucosyltransferase enzyme and has previously been associated with Crohn's disease.
|
24586186 |
2014 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although a causing viral infectious agent remains untraceable in Crohn's disease, most recent genome-wide association studies have linked the FUT2 W143X mutation (resulting in asymptomatic norovirus infection) with the pathogenesis of Crohn's ileitis and with vitamin B12 deficiency (i.e., a known risk factor for Crohn's disease with ileal involvement).
|
24351661 |
2014 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the colonic microbiota of non-secretors is altered at both the compositional and functional levels, affecting the host mucosal state and potentially explaining the association of FUT2 genotype and CD susceptibility.
|
24781901 |
2014 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study aimed to analyze associations of CD with FUT2 and FUT3 polymorphisms in Chinese population.
|
24720527 |
2014 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No effect on Crohn's disease risk was detected for ABO variants, whereas an association was observed between the FUT2 polymorphism and Crohn's disease susceptibility in the Belgian sample, but not in the Italian cohort.
|
24268527 |
2014 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recent research has revealed that the FUT2 gene is associated with Crohn's disease (CD) in western populations.
|
21725903 |
2011 |
|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Individuals lacking a functional copy of FUT2 are known as "nonsecretors" and display an array of differences in susceptibility to infection and disease, including Crohn disease.
|
22068912 |
2011 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We demonstrated replication in an independent cohort of 1174 CD cases and 357 controls between the four primary FUT2 single nucleotide polymorphisms (SNPs) and CD (rs602662, combined P-value 4.90x10(-8)) and also association with FUT2 W143X (P=2.6x10(-5)).
|
20570966 |
2010 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
20570966 |
2010 |
|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
20570966 |
2010 |
|
VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1
|
0.400 |
CausalMutation
|
phenotype |
CLINVAR |
A second nonsecretor allele of the blood group alpha(1,2)fucosyl-transferase gene (FUT2).
|
8928486 |
1996 |
|
VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1
|
0.400 |
CausalMutation
|
phenotype |
CLINVAR |
Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency.
|
8755920 |
1996 |
|
VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1
|
0.400 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
|
|
|
|
Infection caused by Norovirus
|
0.370 |
Biomarker
|
group |
BEFREE |
We followed a community-based birth cohort of 194 children in Ecuador with the aim to estimate (1) the incidence of norovirus gastroenteritis from birth to age 3 years, (2) the protective effect of norovirus infection against subsequent infection/disease, and (3) the association of infection and disease with FUT2 secretor status.
|
25505295 |
2015 |