|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
LOX-1 and CD15 expression levels in tumor tissue were determined by immunofluorescent microscopy.
|
31447588 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taking into account the relevance of glycans in tumor biology and considering that they can act as targets of therapies and biomarkers, the present study evaluated the expression of LeX, SLeX, STn and NGcGM3 in MB49 and MB49-I cells, in different growth conditions such as monolayer cultures, three-dimensional multicellular spheroids and mouse heterotopic and orthotopic tumors.
|
30867744 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By immunohistochemistry, Lewis x was detected in 34/79 (43%) tumor samples, while sialyl Lewis x only in 11/79 (14%).
|
28681122 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, DC<sub>LEX-TGF-β1si</sub> inhibited tumor growth more efficiently than other formulations did as the preventive or therapeutic tumor vaccine.
|
28601924 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results also showed that miR-200b suppressed FUT4 expression and inhibited tumor growth and metastasis in MCF-7 and MDA-MB-231 breast cancer cells, as well as in the xenografted tumor tissues and metastatic lung tissues. miR-200b decreased the α1,3-fucosylation and LeY biosynthesis on epidermal growth factor receptor (EGFR), as well as inactivation of EGFR and downstream phosphoinositide-3 kinase/Akt signaling pathway.
|
28692034 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, whether Rg3-induced inhibition on tumor development involves reduced NF-κB signaling and FUT4 expression remains unknown.
|
26094873 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Sialyl Lewis X (sLe X, CD15s) is a key antigen produced on tumor cell surfaces during multidrug resistance (MDR) development.
|
24953795 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found that TSC marker CD133 was richly expressed after chemotherapy in recurrent ETANTR, while CD15 is depleted compared with that expressed in the original tumor, suggesting that CD133+ cells likely survived initial treatment, further contributing to formation of the recurrent tumor.
|
23865520 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Enhanced fucosyltransferase IV (FUT4) expression correlates with increased tumor malignancy in many carcinomas.
|
22287018 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The levels of Lewis antigens after IL-1β or IL-6 stimulation decreased for sialyl-Lewis x, and no significant differences were found in the rest of the Lewis antigens analyzed, as it was also observed in subcutaneous mice tumors from MKN45 cells treated with IL-1β or IL-6.
|
21365246 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The effects of cimetidine on tumor adhesion were almost nullified by pre-incubation with E-selectin and sialyl Lewis x antibody.
|
21327325 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Heterogeneous lineages of cancer cells in the bulk of the tumour arise through differentiation of SSEA-1(+) fibroblasts, and differentiation is associated with loss of tumorigenic potential.
|
21857669 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
They showed an increase of the tumour associated antigen sialyl-Lewis(x).
|
20824144 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.
|
19185848 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Treatment of A431 cells that were inoculated into the nude mice with FUT1 siRNA or FUT4 siRNA greatly impeded tumor growth.
|
18023290 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The effects of andrographolide on tumor adhesion were almost nullified by pre-incubation with E-selectin and sialyl Lewis(X) antibody.
|
17695536 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Consecutive WT1 vaccination at 2-week intervals resulted in a reduction in tumor markers such as chorio-embryonic antigen (CEA) and sialyl Lewis (x) (SLX) and by a transient decrease in tumor size.
|
15031530 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine the role of sialyl Lewis x oligosaccharides in tumor dissemination, human melanoma MeWo cells, which do not express sialyl Lewis x, were transfected with alpha1,3-fucosyltransferase III (FTIII), and cell lines expressing different amounts of sialyl Lewis x were isolated.
|
12370411 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor-infiltrating CD15(+) cells displaying DC morphology could also be detected by immunohistochemistry in the original tumor specimens from which discrete melanoma cell lines under investigation were derived.
|
11165714 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Specific detection of sialyl Lewis X determinant carried on the mucin GlcNAcbeta1-->6GalNAcalpha core structure as a tumor-associated antigen.
|
9642161 |
1998 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Survival of the patients whose tumors showed strong expression of Fuc-TIV and/or FucT-VII was significantly shorter than that of the patients whose tumors did not express either Fuc-TIV or Fuc-TVII.
|
8542587 |
1996 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunologic study of the tumor mass showed expressions of membrane/cytoplasmic CD 13 and CD 15 antigens.
|
2322103 |
1990 |