IFI6, interferon alpha inducible protein 6, 2537

N. diseases: 26; N. variants: 0
Disease: Hepatitis C ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.030 Biomarker disease BEFREE Conclusion: A lncRNA, lncRNA-IFI6, regulates antiviral innate immunity in the JFH1 HCV infection model. lncRNA-IFI6 regulates HCV infection independently of the JAK-STAT pathway. lncRNA-IFI6 exerts its regulatory function via promoter activation and histone modification of IFI6 through its spatial domain. 30199576 2019
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.030 Biomarker disease BEFREE Notably, IFI6 has little effect on other mammalian RNA viruses, including the related Flaviviridae family member hepatitis C virus, which replicates in double-membrane vesicles that protrude outwards from the ER. 30224801 2018
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.030 Biomarker disease BEFREE Taken together, the results from our study support a model where IFI6 inhibits HCV entry by impairing EGFR mediated CD81/CLDN1 interactions. 25757571 2015