Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicate that farrerol can effectively activate Nrf2 and can serve as a therapeutic target in the treatment of acute kidney injury (AKI).
|
31849693 |
2019 |
Kidney Failure, Acute
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CA prevented MTX-induced AKI through activation of Nrf2/ARE/HO-1 signaling, and attenuation of ROS-induced activation of NF-κB/NLRP3 inflammasome signaling.
|
31037316 |
2019 |
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
5-Aminolevulinic acid exerts renoprotective effect via Nrf2 activation in murine rhabdomyolysis-induced acute kidney injury.
|
29068550 |
2019 |
Kidney Failure, Acute
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ergo, our findings suggest that GSK3β-mediated Keap1-independent regulation of Nrf2 may serve as an actionable therapeutic target for modifying the long-term sequelae of AKI.
|
31349118 |
2019 |
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nrf2 Plays a Protective Role Against Intravascular Hemolysis-Mediated Acute Kidney Injury.
|
31333462 |
2019 |
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
OIP (i) activates the cytoprotective Nrf2, but not the P21, pathway; (ii) suppresses post-ischemic P21 induction and renal senescence; and (iii) confers marked protection against ischemic ARF.
|
29522116 |
2018 |
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
To explore the effect of PI3K/Nrf2 pathway on acute kidney injury (AKI) induced by endotoxic shock in rats by construction of the endotoxic shock rat model.
|
30178867 |
2018 |
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have analyzed numerous findings showing that Nrf2 induction protects against oxidative stress and modulates inflammation in acute kidney injury and chronic kidney disease progression.
|
28494744 |
2017 |
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanism of myocardial ischemia/reperfusion-induced acute kidney injury through DJ-1/Nrf2 pathway in diabetic rats.
|
29104636 |
2017 |
Kidney Failure, Acute
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SnPP specifically accumulates within proximal tubule cells; transient "catalytic" Fe overload and oxidative stress result; Nrf2-cytoprotective pathways are upregulated; and these changes help protect against ischemic AKI.
|
28586635 |
2017 |
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, Nrf2 may be a promising therapeutic target for preventing acute kidney injury to chronic kidney disease transition.
|
27789056 |
2017 |
Kidney Failure, Acute
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Exogenous αKlotho increases endogenous anti-oxidative capacity partly via activation of the Nrf2 pathway to protect lungs against injury caused by direct hyperoxia exposure or AKI.
|
28347910 |
2017 |
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings showed the novel transcriptional role of miR140-5p in the expression of Nrf2 and miR-140-5p protected against Cisplatin induced oxidative stress by activating Nrf2-dependent antioxidant pathway, providing a potentially therapeutic target in acute kidney injury.
|
28928081 |
2017 |