We performed genome-wide screening followed by multicenter validation in 8 cohorts consisting of 21 828 participants of Han ethnicity and identified 3 novel intragenic SNPs (single nucleotide polymorphisms), rs9486729 (<i>SCML4</i> [Scm polycomb group protein-like 4]; odds ratio, 1.25; 95% CI, 1.17-1.34; <i>P</i>=3.51×10<sup>-11</sup>), rs17165136 (<i>THSD7A</i> [thrombospondin type 1 domain-containing 7A]; odds ratio 1.28; 95% CI, 1.21-1.35; <i>P</i><1.00×10<sup>-25</sup>), and rs852787 (<i>DAB1</i> [disabled-1]; odds ratio, 1.29; 95% CI, 1.21-1.38; <i>P</i>=2.02×10<sup>-14</sup>), associated with CAD with genome-wide significance.