|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
SMARCB1 (INI-1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center.
|
31729110 |
2020 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
NUT Carcinoma of the Salivary Glands: Clinicopathologic and Molecular Analysis of 3 Cases and a Survey of NUT Expression in Salivary Gland Carcinomas.
|
29649019 |
2018 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We evaluated 240 cases (133 in whole-tissue sections; 107 in tissue microarrays), including 76 peripheral neuroblastic tumours (median age 2 years; including four adults) and 164 other tumours: 44 Wilms tumours; 20 Ewing sarcomas; 10 each of CIC-rearranged round cell sarcomas, poorly differentiated synovial sarcomas, lymphoblastic lymphomas, alveolar rhabdomyosarcomas, embryonal rhabdomyosarcomas, mesenchymal chondrosarcomas, Merkel cell carcinomas, olfactory neuroblastomas, and melanomas; and five each of NUT midline carcinomas and desmoplastic small round cell tumours.
|
28640941 |
2017 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we present the first integrative analysis of whole-genome sequencing, transcriptome sequencing and cytogenetic characterization of NUT midline carcinomas.
|
28203693 |
2017 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this regard, poorly differentiated carcinomas lacking glandular differentiation mandate testing for NUT expression by immunohistochemistry.
|
28407756 |
2017 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
After partial parotidectomy, the diagnosis of a NMC was made based on the presence of t(15;19)(q14;p13.1) and BRD4/NUT fusion gene demonstrated by fluorescence in situ hybridization (FISH).
|
26027633 |
2016 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628.
|
26976114 |
2016 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Given their aggressive and invasive nature, NUT midline carcinomas present a therapeutic dilemma.
|
26667959 |
2016 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Regardless of the level of tumor markers, immunohistochemistry for NUT should be performed in cases of poorly differentiated carcinomas without glandular differentiation arising in the midline structures.
|
27855672 |
2016 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We evaluated whole-tissue sections from 270 cases: 40 Ewing sarcomas (4 with atypical/large cell features), 20 CIC-DUX4 sarcomas, 5 BCOR-CCNB3 sarcomas, 9 unclassified round cell sarcomas, 10 poorly differentiated synovial sarcomas, 10 lymphoblastic lymphomas, 10 alveolar rhabdomyosarcomas, 10 embryonal rhabdomyosarcomas, 10 Merkel cell carcinomas, 10 small cell carcinomas, 20 melanomas, 5 NUT midline carcinomas, 10 Wilms tumors, 10 neuroblastomas, 10 olfactory neuroblastomas, 12 mesenchymal chondrosarcomas, 10 angiomatoid fibrous histiocytomas, 10 clear cell sarcomas, 5 gastrointestinal clear cell sarcoma-like tumors, 5 desmoplastic small round cell tumors, 10 extraskeletal myxoid chondrosarcomas, 10 soft tissue and cutaneous myoepitheliomas, and 19 myoepithelial carcinomas.
|
26847175 |
2016 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We identified eight cases of primary pulmonary NMC in our consult practice over 4 years and, using a NUT immunohistochemistry screen, retrospectively identified one additional case from 166 (0.6%) consecutive in-house biopsies of lung carcinomas lacking glandular differentiation.
|
26001144 |
2015 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
NUT (nuclear protein in testis) carcinomas are exceedingly rare neoplasms with specific molecular alterations and often follow a devastating course.
|
26490121 |
2015 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The SMARCB1-deficient carcinomas did not harbor human papillomavirus or NUT-1 alterations.
|
25007146 |
2014 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These studies identify this stem cell marker as a novel BRD4-NUT target that supports the highly aggressive transforming activity of t(15;19) carcinomas.
|
24736545 |
2014 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Thus, the generation of BRD4-NUT fusion transcripts through post-translocation RNA-splicing appears to be a common feature of these carcinomas that has not previously been appreciated, with the mechanism facilitating the expression of alternative isoforms of the fusion.
|
23128391 |
2013 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The cell lines also did not contain the BRD4/NUT gene rearrangement [t(15,19)] seen in midline carcinomas nor did they contain overexpressed nuclear protein in testis (NUT) genes.
|
23374840 |
2013 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
NUT positivity was detected in 2 of 13 (15%) carcinomas diagnosed as sinonasal undifferentiated carcinoma and in 1 of 87 (1%) carcinomas diagnosed as squamous cell carcinoma.
|
22534723 |
2012 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A series of 148 TETs (37 carcinomas and 111 thymomas) were examined for NUT expression and rearrangement.
|
22425924 |
2012 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Midline carcinomas associated with the nuclear protein in testis (NUT) gene rearrangement are rare, aggressive tumors that have been diagnosed most commonly in the head, neck, mediastinum, and upper aerodigestive tract.
|
22849529 |
2012 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
More widespread use of a newly available NUT immunohistochemical stain will facilitate the diagnosis of NUT rearranged carcinomas.
|
22032580 |
2011 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Demystified molecular pathology of NUT midline carcinomas.
|
18552174 |
2010 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Carcinomas of the upper aerodigestive tract with rearrangement of the nuclear protein of the testis (NUT) gene (NUT midline carcinomas).
|
19550370 |
2009 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These carcinomas are characterized by the presence of a chromosomal rearrangement of nuclear protein in testis the (NUT) gene on chromosome 15 (15q14), resulting from a chromosomal translocation most commonly involving the BRD4 gene on chromosome 19p13.
|
19561446 |
2009 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
To investigate the functional role of BRD-NUT fusion proteins in NMCs, we investigated the effects of siRNA-induced BRD3-NUT and BRD4-NUT withdrawal.
|
17934517 |
2008 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A subset of poorly differentiated carcinomas is characterized by the translocation t(15;19)(q13;p13), resulting in a BRD4/NUT fusion gene.
|
16435379 |
2007 |