GAD1, glutamate decarboxylase 1, 2571

N. diseases: 245; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE The response rate, as measured by a 50% decrease in scores, for those with initial scores ≥10 was 58.6% for depression (PHQ-9) and 50% for anxiety (GAD-7). 28165775 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE A binary logistic regression analyses were conducted to test the association between all four ratings in GAD-7 (anxiety) and PHQ-9 (depression) scales subitems as covariates, and migraine vs no headache as the outcome. 28324317 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE The overall findings suggest that the workbook format was no less effective or acceptable than the validated online format.Significant improvements (avg. improvement; Internet Group vs Workbook Group) in levels of disability (PDI: 16% vs 24%; RMDQ: 12% vs 15%), anxiety (GAD-7: 36% vs 26%), and depression (PHQ-9: 36% vs 36%) were observed in both groups immediately posttreatment. 28394850 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE Furthermore, self-rating questionnaires were used to assess somatic symptom severity (PHQ-15), depression severity (PHQ-9) and anxiety severity (GAD-7). 28554368 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE Primary outcomes included the Patient Health Questionnaire-9 (PHQ-9) for depression and the Generalized Anxiety Disorder-7 (GAD-7) for anxiety. 28057609 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE Participants were 307 psychiatry outpatients with depression; assessed at baseline, 3-, and 6-months on symptom (PHQ-9 and GAD-7), functioning (SF-12) and past-month marijuana use for a substance use intervention trial. 28242498 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE The resulting groups were characterized with regard to Quality of Life (MacNew), anxiety and depression (GAD-7 and PHQ-9) and resilience (RS-13). 28006984 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 AlteredExpression disease BEFREE There were a significant 58% increase of SCN GAD65/67-ir and a significant 169% increase of SCN GAD67-mRNA in the depression group. 28608287 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE Clinical diagnoses, the Patient Health Questionnaire depression (PHQ-9) and somatization modules (PHQ-15), the Generalized Anxiety Disorder Scale (GAD-7), the Liebowitz Social Anxiety Scale (LSAS), and the Short-Form-12 Health Survey (SF-12) were used in the clinical sample. 29178857 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE This hypothesis is supported by a higher rate of suicide among male Test cricketers when compared with the UK male general population.<sup>1</sup> METHODS: This study ascertained rates of anxiety and depression by screening professional cricket players using the Generalised Anxiety Disorder Questionnaire (GAD-7) and Patient Health Questionnaire (PHQ-9). 28490460 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like. 25106036 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease PSYGENET FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like. 25106036 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE In a recent association study in depression, which is highly comorbid with panic disorder, GAD1 risk allele associations were restricted to females. 22662185 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease PSYGENET In a recent association study in depression, which is highly comorbid with panic disorder, GAD1 risk allele associations were restricted to females. 22662185 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease PSYGENET We also found suggestive associations in women for GAD1, GRIA3, and BDNF with depression accompanied by fatigue, and for CRHR1 with depression accompanied by early morning awakenings. 19548263 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE For GAD age at onset, family history, biology and symptomatology are close to those of depression. 18344044 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease PSYGENET As a consequence broader entities such as depression-GAD spectrum, panic-phobias spectrum and OCD spectrum including eating disorders and pathological gambling are taken into consideration; (c) Diagnostic categories use thresholds to delimitate a border with normals.This creates "subthreshold" conditions. 18344044 2008