GAK, cyclin G associated kinase, 2580

N. diseases: 13; N. variants: 6
Disease: Hepatitis C ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.040 Biomarker disease BEFREE We demonstrated that the host kinases AAK1 and GAK regulate HCV infection by controlling these clathrin-associated APs. 29535204 2018
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.040 Biomarker disease BEFREE We previously reported that AAK1 and GAK, kinase regulators of the host adaptor proteins AP1 and AP2, are essential for hepatitis C virus (HCV) infection, but the underlying mechanism and relevance to other viruses or in vivo infections remained unknown. 28240606 2017
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.040 Biomarker disease BEFREE AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets. 25653444 2015
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.040 Biomarker disease BEFREE Furthermore, AAK1 and GAK, serine/threonine kinases known to stimulate binding of AP2M1 to host cargo proteins, regulate core-AP2M1 binding and are essential for HCV assembly. 22916011 2012