|
Colorectal Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The observed statistically significant associations included a decreased CRC risk for TGFBR1 IVS7G+24A minor allele carriers (odds ratio (OR): 0.72, 95% confidence interval (CI): 0.53-0.97), less aggressive tumors with Dukes' stage A+B for carriers of LTBP4 Thr750Ala and BAMBI T-779A minor alleles (OR: 0.58, 95%CI: 0.36-0.93 and OR: 0.51, 95%CI: 0.29-0.89, respectively) and worse survival for FURIN C-229T heterozygotes (hazard ratio: 1.63, 95%CI: 1.08-2.46).
|
19998449 |
2010 |
|
Neoplasm Metastasis
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
To provide direct evidence for the inverse correlation between the production of endogenous NO and the ability of K-1735 cells to produce metastasis in syngeneic mice, highly metastatic clone 4 cells (C4.P), which express low levels of iNOS, were transfected with a functional iNOS (C4.L8), inactive mutated iNOS (C4.S2), or neomycin resistance (C4.Neo) genes in medium containing 3 mM NMA.
|
8691063 |
1996 |
|
Neuroblastoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
From an extended series neuroblastoma cases evaluated for MYCN amplification (MNA) at the "G. Gaslini" Hospital 15 (4 with and 11 without NMA) underwent myeloablative therapy and bone marrow transplantation (MAT-ABMT).
|
1855077 |
1991 |
|
Obesity
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Alterations in BAMBI may play a role in the (patho)physiology of obesity, and manipulation of BAMBI may present a novel therapeutic approach to improve adipose tissue function.
|
22187378 |
2012 |
|
Mental Retardation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In our analyses of more than 536 cases of clinically undiagnosed multiple congenital anomalies and mental retardation (MR) by microarray-based comparative genomic hybridization, we detected two non-consanguineous unrelated patients with microdeletions at 10p11.23-p12.1, which overlapped for 957 kb, including four protein-coding genes: ARMC4, MPP7, WAC and BAMBI.
|
22258158 |
2012 |
|
Central neuroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
From an extended series neuroblastoma cases evaluated for MYCN amplification (MNA) at the "G. Gaslini" Hospital 15 (4 with and 11 without NMA) underwent myeloablative therapy and bone marrow transplantation (MAT-ABMT).
|
1855077 |
1991 |
|
Intellectual Disability
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In our analyses of more than 536 cases of clinically undiagnosed multiple congenital anomalies and mental retardation (MR) by microarray-based comparative genomic hybridization, we detected two non-consanguineous unrelated patients with microdeletions at 10p11.23-p12.1, which overlapped for 957 kb, including four protein-coding genes: ARMC4, MPP7, WAC and BAMBI.
|
22258158 |
2012 |
|
Childhood Neuroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
From an extended series neuroblastoma cases evaluated for MYCN amplification (MNA) at the "G. Gaslini" Hospital 15 (4 with and 11 without NMA) underwent myeloablative therapy and bone marrow transplantation (MAT-ABMT).
|
1855077 |
1991 |
|
Fibrosis, Liver
|
0.330 |
Biomarker
|
disease |
CTD_human |
In conclusion, the TGF-β and LPS-induced miR-942 mediates HSC activation through downregulation of BAMBI in human liver fibrosis.
|
30097701 |
2018 |
|
Fibrosis, Liver
|
0.330 |
Biomarker
|
disease |
BEFREE |
BAMBI is lower in human fatty liver with a higher susceptibility to liver fibrosis and negatively correlates with BMI of the donors.
|
21496456 |
2011 |
|
Cardiomegaly
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
|
Congestive heart failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
|
Left-Sided Heart Failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
|
Liver Cirrhosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis.
|
30097701 |
2018 |
|
Heart Failure, Right-Sided
|
0.300 |
Biomarker
|
disease |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
|
Cardiac Hypertrophy
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
|
Myocardial Failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
|
Heart Decompensation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
BAMBI, a TGF-β responsive tumor suppressor, was induced by FOXA1 in NPC cells.
|
30392786 |
2019 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Reconstitution of BAMBI expression in NSCLC cells resulted in a marked reduction of TGFβ-induced EMT, migration, and invasion in vitro, along with reduced tumor burden and tumor growth in vivo In conclusion, our results demonstrate how BAMBI downregulation drives the invasiveness of NSCLC, highlighting TGFβ signaling as a candidate therapeutic target in this setting.
|
27197161 |
2016 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) gene encodes a transmembrane protein and is involved in multiple physiological and pathological processes, such as inflammatory response, tumor development and progression, cell proliferation and differentiation.
|
30580997 |
2019 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
BAMBI regulates CRC metastasis by connecting the Wnt/beta-catenin and TGF-beta-signaling pathways.
|
19328798 |
2009 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The signature included the canonical Wnt target gene BAMBI, which promoted experimental metastasis in mice.
|
26156959 |
2016 |
|
Neuroblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
AXL was silenced in two non-NMA NBL cell lines by using a lentiviral shRNA construct that was able to transduce these cell lines with more than 90% infection efficiency.
|
23523856 |
2013 |