Fibrosis, Liver
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the TGF-β and LPS-induced miR-942 mediates HSC activation through downregulation of BAMBI in human liver fibrosis.
|
30097701 |
2018 |
Fibrosis, Liver
|
0.330 |
Biomarker
|
disease |
CTD_human |
In conclusion, the TGF-β and LPS-induced miR-942 mediates HSC activation through downregulation of BAMBI in human liver fibrosis.
|
30097701 |
2018 |
Fibrosis, Liver
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
In summary, our study demonstrates that LPS- and TNF-α-induced NF-κBp50-HDAC1 interaction represses BAMBI transcriptional activity, which contributes to TLR4-mediated enhancement of TGF-β signaling in HSCs during liver fibrosis.
|
24448807 |
2014 |
Fibrosis, Liver
|
0.330 |
Biomarker
|
disease |
BEFREE |
BAMBI is lower in human fatty liver with a higher susceptibility to liver fibrosis and negatively correlates with BMI of the donors.
|
21496456 |
2011 |
Cardiomegaly
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
Heart failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
Congestive heart failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
Left-Sided Heart Failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
Liver Cirrhosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis.
|
30097701 |
2018 |
Heart Failure, Right-Sided
|
0.300 |
Biomarker
|
disease |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
Cardiac Hypertrophy
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
Myocardial Failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
Heart Decompensation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
|
29394407 |
2018 |
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
BAMBI, a TGF-β responsive tumor suppressor, was induced by FOXA1 in NPC cells.
|
30392786 |
2019 |
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) gene encodes a transmembrane protein and is involved in multiple physiological and pathological processes, such as inflammatory response, tumor development and progression, cell proliferation and differentiation.
|
30580997 |
2019 |
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Reconstitution of BAMBI expression in NSCLC cells resulted in a marked reduction of TGFβ-induced EMT, migration, and invasion in vitro, along with reduced tumor burden and tumor growth in vivo In conclusion, our results demonstrate how BAMBI downregulation drives the invasiveness of NSCLC, highlighting TGFβ signaling as a candidate therapeutic target in this setting.
|
27197161 |
2016 |
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
The tumor promoting impact of BAMBI mRNA overexpression in vitro could not be confirmed in primary tumor samples, and while nearly all tumor samples showed up-regulation of BAMBI (37.3% 1+, 39.2% 2+, and 16.7% 3+, respectively) compared to undetectable BAMBI in healthy pre- and post-menopausal ovarian epithelia, no impact of BAMBI expression on recurrence free and overall survival could be observed.
|
20189233 |
2010 |
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Among these, the transforming growth factor (TGF) beta inhibitor BAMBI was highly expressed in approximately half of metastatic primary tumors and metastases but not in nonmetastatic tumors.
|
19328798 |
2009 |
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The signature included the canonical Wnt target gene BAMBI, which promoted experimental metastasis in mice.
|
26156959 |
2016 |
Colorectal Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The observed statistically significant associations included a decreased CRC risk for TGFBR1 IVS7G+24A minor allele carriers (odds ratio (OR): 0.72, 95% confidence interval (CI): 0.53-0.97), less aggressive tumors with Dukes' stage A+B for carriers of LTBP4 Thr750Ala and BAMBI T-779A minor alleles (OR: 0.58, 95%CI: 0.36-0.93 and OR: 0.51, 95%CI: 0.29-0.89, respectively) and worse survival for FURIN C-229T heterozygotes (hazard ratio: 1.63, 95%CI: 1.08-2.46).
|
19998449 |
2010 |
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
BAMBI regulates CRC metastasis by connecting the Wnt/beta-catenin and TGF-beta-signaling pathways.
|
19328798 |
2009 |
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
We observed an inverse correlation between level of BAMBI expression and metastasis-free survival time of patients.
|
19328798 |
2009 |
Colorectal Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we have recently shown that Wnt/beta-catenin signaling activates transcription of BAMBI and that BAMBI expression is aberrantly elevated in most colorectal carcinomas.
|
15240101 |
2004 |
Neoplasm Metastasis
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
To provide direct evidence for the inverse correlation between the production of endogenous NO and the ability of K-1735 cells to produce metastasis in syngeneic mice, highly metastatic clone 4 cells (C4.P), which express low levels of iNOS, were transfected with a functional iNOS (C4.L8), inactive mutated iNOS (C4.S2), or neomycin resistance (C4.Neo) genes in medium containing 3 mM NMA.
|
8691063 |
1996 |
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Both BAMBI and ELMO1 had the same patterns of expression with miR-HCC2 in HCC tissues.
|
31293644 |
2019 |