|
ovarian neoplasm
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
|
23535730 |
2013 |
|
Malignant neoplasm of ovary
|
0.400 |
GeneticVariation
|
disease |
GWASDB |
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
|
23535730 |
2013 |
|
ovarian neoplasm
|
0.400 |
Biomarker
|
disease |
CTD_human |
Analysis of HOXD1, MYC, TIPARP and SKAP1 at these loci and of BNC2 at 9p22 supports a functional role for these genes in ovarian cancer development.
|
20852632 |
2010 |
|
ovarian neoplasm
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of HOXD1, MYC, TIPARP and SKAP1 at these loci and of BNC2 at 9p22 supports a functional role for these genes in ovarian cancer development.
|
20852632 |
2010 |
|
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
CTD_human |
Analysis of HOXD1, MYC, TIPARP and SKAP1 at these loci and of BNC2 at 9p22 supports a functional role for these genes in ovarian cancer development.
|
20852632 |
2010 |
|
Malignant neoplasm of ovary
|
0.400 |
GeneticVariation
|
disease |
GWASDB |
Analysis of HOXD1, MYC, TIPARP and SKAP1 at these loci and of BNC2 at 9p22 supports a functional role for these genes in ovarian cancer development.
|
20852632 |
2010 |
|
Alcoholic Intoxication, Chronic
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Interestingly, several genes (TESK2, TIPARP, THEMIS, ABLIM1, RFX4, STON2 and LILRA1) are associated with three personality traits with p < 10(-3) using single trait analysis and AD.
|
21547531 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, several genes (TESK2, TIPARP, THEMIS, ABLIM1, RFX4, STON2 and LILRA1) are associated with three personality traits with p < 10(-3) using single trait analysis and AD.
|
21547531 |
2012 |
|
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Epithelial ovarian cancer
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
|
25581431 |
2015 |
|
Corpuscular Hemoglobin Concentration Mean
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Seventy-five genetic loci influencing the human red blood cell.
|
23222517 |
2012 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Moreover, the mutations and DNA methylation of TIPARP might contribute to TIPARP dysregulation in breast cancer.
|
31695491 |
2019 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Interactors with TIPARP were significantly enriched in telomere maintenance, telomere organization and mainly participated in pathways in cancer.
|
31695491 |
2019 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Moreover, the mutations and DNA methylation of TIPARP might contribute to TIPARP dysregulation in breast cancer.
|
31695491 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Interactors with TIPARP were significantly enriched in telomere maintenance, telomere organization and mainly participated in pathways in cancer.
|
31695491 |
2019 |
|
Steatohepatitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these data illustrate that TIPARP is an important negative regulator of AHR activity, and that its specific loss in hepatocytes is sufficient to increase sensitivity to dioxin-induced steatohepatitis and lethality.
|
29873790 |
2018 |
|
Malignant neoplasm of breast
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We also observed associations of borderline significance with the TIPARP rs2665390 polymorphism, which was previously found to be associated with ovarian and breast cancer, and with the EXOC1 rs13117307 polymorphism, which has been linked to cervical cancer in a large study in a Chinese population.
|
28505207 |
2017 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
PARP-1, PARP-2 and PARP-7 are related to metabolic diseases such as diabetes, alcoholic and non-alcoholic fatty liver disease (AFLD, NAFLD), or on a broader perspective to Warburg metabolism in cancer or the metabolic diseases accompanying aging.
|
28013023 |
2017 |
|
Breast Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We also observed associations of borderline significance with the TIPARP rs2665390 polymorphism, which was previously found to be associated with ovarian and breast cancer, and with the EXOC1 rs13117307 polymorphism, which has been linked to cervical cancer in a large study in a Chinese population.
|
28505207 |
2017 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
PARP-1, PARP-2 and PARP-7 are related to metabolic diseases such as diabetes, alcoholic and non-alcoholic fatty liver disease (AFLD, NAFLD), or on a broader perspective to Warburg metabolism in cancer or the metabolic diseases accompanying aging.
|
28013023 |
2017 |
|
Steatohepatitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Dioxin-treated Tiparp(-/-) mice exhibited increased liver steatosis and hepatotoxicity.
|
25975270 |
2015 |
|
Hepatitis
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Knockdown of TiPARP reduced viral replication and increased interferon expression, suggesting that TiPARP functions in a pro-viral manner during MHV infection.
|
31694960 |
2020 |
|
Hepatitis A
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of TiPARP reduced viral replication and increased interferon expression, suggesting that TiPARP functions in a pro-viral manner during MHV infection.
|
31694960 |
2020 |
|
Chylous Ascites
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
3-Methylcholanthrene Induces Chylous Ascites in TCDD-Inducible Poly-ADP-Ribose Polymerase (<i>Tiparp</i>) Knockout Mice.
|
31083300 |
2019 |
|
Meningioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We report the up regulation of AHR pathway genes like aryl hydrocarbon receptor nuclear translocator (ARNT), aldehyde dehydrogenase1family memberA3 (ALDH1A3), cytochrome P450, family1, subfamily A polypeptide1 (CYP1A1) and TCCD induced poly ADP ribose polymerase (TIPARP) gene expression in human meningioma.
|
29302888 |
2018 |