ACOT11, acyl-CoA thioesterase 11, 26027

N. diseases: 18; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement 		0.100 GeneticVariation phenotype GWASCAT Co-regulatory networks of human serum proteins link genetics to disease. 30072576 2018
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement 		0.100 GeneticVariation phenotype GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0017638
Disease: Glioma
Glioma 		0.100 GeneticVariation disease GWASDB Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. 19578366 2009
CUI: C0085136
Disease: Central Nervous System Neoplasms
Central Nervous System Neoplasms 		0.100 GeneticVariation group GWASDB Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. 19578366 2009
CUI: C0152128
Disease: Drug withdrawal syndrome
Drug withdrawal syndrome 		0.010 Biomarker disease BEFREE Recently, three predictive scores in the field of Autoimmune Thyroid Disease (AITD) have been introduced: The Thyroid Hormones Event Amsterdam-THEA score: a predictive score of the development of overt AITD, the Graves' Events After Therapy-GREAT score: a prediction score for the risk of recurrence after antithyroid drugs withdrawal and the Prediction Graves' Orbitopathy-PREDIGO score: a prediction score for the development of Graves' Orbitopathy in newly diagnosed patients with Graves' hyperthyroidism. 31137010 2019
CUI: C0153676
Disease: Secondary malignant neoplasm of lung
Secondary malignant neoplasm of lung 		0.010 Biomarker disease BEFREE At the final follow-up, one of them (1/9, 11%) experienced local recurrence in soft tissue and received another resection surgery, and four (4/9, 44%) patients developed lung metastases. 31399083 2019
CUI: C0339143
Disease: Thyroid associated opthalmopathies
Thyroid associated opthalmopathies 		0.010 Biomarker disease BEFREE Recently, three predictive scores in the field of Autoimmune Thyroid Disease (AITD) have been introduced: The Thyroid Hormones Event Amsterdam-THEA score: a predictive score of the development of overt AITD, the Graves' Events After Therapy-GREAT score: a prediction score for the risk of recurrence after antithyroid drugs withdrawal and the Prediction Graves' Orbitopathy-PREDIGO score: a prediction score for the development of Graves' Orbitopathy in newly diagnosed patients with Graves' hyperthyroidism. 31137010 2019
CUI: C3840565
Disease: Autoimmune thyroid disease (AITD)
Autoimmune thyroid disease (AITD) 		0.010 Biomarker disease BEFREE Recently, three predictive scores in the field of Autoimmune Thyroid Disease (AITD) have been introduced: The Thyroid Hormones Event Amsterdam-THEA score: a predictive score of the development of overt AITD, the Graves' Events After Therapy-GREAT score: a prediction score for the risk of recurrence after antithyroid drugs withdrawal and the Prediction Graves' Orbitopathy-PREDIGO score: a prediction score for the development of Graves' Orbitopathy in newly diagnosed patients with Graves' hyperthyroidism. 31137010 2019
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.010 AlteredExpression disease BEFREE When fed a high-fat diet, Them1 expression in liver promoted excess steatosis in the setting of reduced rates of fatty acid oxidation and preserved glycerolipid synthesis. 29208699 2018
CUI: C0011847
Disease: Diabetes
Diabetes 		0.010 Biomarker disease BEFREE We recruited women with pre-existing or gestational diabetes in a singleton pregnancy from 34 to 37 weeks' gestation and randomly assigned them (1:1) to either expressing breastmilk twice per day from 36 weeks' gestation (antenatal expressing) or standard care (usual midwifery and obstetric care, supplemented by support from a diabetes educator). 28589894 2017
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.010 Biomarker group BEFREE We recruited women with pre-existing or gestational diabetes in a singleton pregnancy from 34 to 37 weeks' gestation and randomly assigned them (1:1) to either expressing breastmilk twice per day from 36 weeks' gestation (antenatal expressing) or standard care (usual midwifery and obstetric care, supplemented by support from a diabetes educator). 28589894 2017
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.010 Biomarker phenotype BEFREE We recruited women with pre-existing or gestational diabetes in a singleton pregnancy from 34 to 37 weeks' gestation and randomly assigned them (1:1) to either expressing breastmilk twice per day from 36 weeks' gestation (antenatal expressing) or standard care (usual midwifery and obstetric care, supplemented by support from a diabetes educator). 28589894 2017
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.010 Biomarker disease BEFREE The proliferation of the lung adenocarcinoma cell lines CL1-0 and CL1-5 was inhibited when ACOT11 and ACOT13 were downregulated by short hairpin RNA. 28927126 2017
CUI: C4551720
Disease: Primary Ciliary Dyskinesia
Primary Ciliary Dyskinesia 		0.010 Biomarker disease BEFREE We converted patients' ICS treatments to 180 μg or 200 μg budesonide dry powder inhaler twice daily for the entire duration of the study using the approved dosages in the patients' respective countries and randomly allocated them (1:1; stratified by blood eosinophil count [<300 cells per μL vs ≥300 cells per μL] and region [USA vs the rest of the world]) with an interactive web-based voice response system to receive subcutaneous placebo or benralizumab 30 mg injections every 4 weeks for 12 weeks. 28545978 2017
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.010 GeneticVariation disease BEFREE Interestingly, the NSCLC patients with antigen-specific T cell responses to these epitopes showed a significantly less frequency of EGFR-T790M mutation than those without them [1 of 7 (14%) vs 9 of 15 (60%); chi-squared test, p  =  0.0449], indicating the negative correlation between the immune responses to the EGFR-T790M-derived epitopes and the presence of EGFR-T790M mutation in NSCLC patients. 24223798 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE We validated methylation of the eight tumor markers genes ZNF154 (P < 0.0001), HOXA9 (P < 0.0001), POU4F2 (P < 0.0001), EOMES (P = 0.0005), ACOT11 (P = 0.0001), PCDHGA12 (P = 0.0001), CA3 (P = 0.0002), and PTGDR (P = 0.0110), the candidate marker of disease progression TBX4 (P < 0.04), and other genes with stage-specific methylation. 21788354 2011
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.010 Biomarker group BEFREE Thus, the fibrillization and aggregation of proteins in the brain is a common theme in a diverse group of neurodegenerative disorders and insight into the pathogenesis of any one of these disorders may have implications for understanding the mechanisms that underlie all these diseases as well as for the discovery of better strategies to treat them [1-3]. 12168561 2002
CUI: C0028754
Disease: Obesity
Obesity 		0.010 Biomarker disease BEFREE BFIT was mapped to syntenic regions of chromosomes 1 (human) and 4 (mouse) associated with body fatness and diet-induced obesity, potentially linking a deficit of BFIT activity with exacerbation of these traits. 11696000 2001