Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL1β and TNFα established a feedback loop to upregulate ARG2 expression via p38 and extracellular regulated kinases 1/2 (ERK1/2) signaling in neuroblastoma and neural crest-derived cells.
|
30545920 |
2019 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, RBM3 is the key mediator of mild hypothermia-related protection against UV in neuroblastoma cells, and the neuroprotective effect might be exerted through interfering with pro-apoptotic signaling pathways p38 and JNK and regulating pro-apoptotic proteins Bax and Bad.
|
28831692 |
2017 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that IFN-β-induced apoptosis of human SH-SY5Y neuroblastoma cells is associated with a long-lasting up-regulation of p38 MAPK activity, stimulation of MK2 and phosphorylation of the pro-survival protein HSP27.
|
25086905 |
2014 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Conditioned medium from the intermittent hypoxia-exposed neuroblastoma cells was found to enhance osteoclastogenesis, up-regulate the mRNAs of osteoclast marker genes including TRAP, CaSR and cathepsin K and induce the activation of ERK, JNK, and p38 in RAW 264.7 cells.
|
25148040 |
2014 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CFM-4 and -5 induced apoptosis in NB cells in part by activating pro-apoptotic stress-activated kinases (SAPKs) p38 and JNK, stimulating CARP-1 expression and cleavage of PARP1, while promoting loss of the oncogenes C and N-myc as well as mitotic cyclin B1.
|
25033461 |
2014 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-κB and p38 MAPK inhibition.
|
23507189 |
2013 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Upregulation of Fas and FasL in Taiwan cobra phospholipase A2-treated human neuroblastoma SK-N-SH cells through ROS- and Ca2+-mediated p38 MAPK activation.
|
19009558 |
2009 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study opens the way to further clinical investigations and suggests a potential benefit of using a combination of bortezomib with an inhibitor of p38 MAPK for the treatment of neuroblastoma relapse.
|
18534018 |
2008 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, in the present study we investigated whether Zn deficiency can increase the susceptibility of human neuroblastoma IMR-32 cells to Pb2+-induced oxidative stress which could trigger the activation of the mitogen-activated protein kinases (MAPKs) c-Jun-N-terminal kinase (JNK) and p38 and subsequently activate transcription factor activator protein-1 (AP-1).
|
16484283 |
2006 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-1beta-induced cPLA2 and COX-2 gene expression is modulated through the p38 MAPK pathway in both neuroglioma and neuroblastoma cells.
|
15950779 |
2005 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
By using a neuroblastoma cell line devoid of neurotrophin receptors and engineered to express either a full-length or a death domain (DD)-truncated form of p75NTR, we demonstrated that Abeta peptide activates the mitogen-activated protein kinases (MAPKs) p38 and c-Jun N-terminal kinase (JNK).
|
15784962 |
2005 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ASK1 resistant neuroblastoma is deficient in activation of p38 kinase.
|
11598801 |
2001 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells.
|
11163539 |
2001 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The ability of p38 MAPK to augment COX-2 expression in human neuroblastoma cells, as shown here, suggests that p38 MAPK may be involved in neuronal expression of COX-2 in AD.
|
11032891 |
2000 |