|
Tuberculosis
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Mincle is encoded by CLEC4E, and we investigated polymorphisms in this gene to assess its role in tuberculosis susceptibility.
|
27363694 |
2016 |
|
Tuberculosis
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The C-type lectin receptor of family 4 member E (CLEC4E) confers protection against tuberculosis in laboratory animals but its function in influencing exposure or resistance to pulmonary tuberculosis (PTB) in humans remains obscure.
|
31075410 |
2019 |
|
Rheumatoid Arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Overall, MINCLE SNP rs10841845 was not associated with susceptibility to RA.
|
22932191 |
2012 |
|
HIV Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Impact of Aging and HIV Infection on the Function of the C-Type Lectin Receptor MINCLE in Monocytes.
|
30239628 |
2019 |
|
Tuberculosis, Pulmonary
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
From our study findings, CLEC4E rs10841845 conferred protection against the development of pulmonary TB with a P value of <0.05 and odds ratio of <1 for all models of genetic inheritance.
|
31075410 |
2019 |
|
Lung diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Blood gene expression profiling detects silica exposure and toxicity.
|
21602193 |
2011 |
|
Tuberculosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
MINCLE is a C-type lectin receptor that recognizes trehalose-6,6'-dimycolate or "cord factor," the most abundant glycolipid in Mycobacterium tuberculosis.
|
30239628 |
2019 |
|
Tuberculosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
We synthesized and evaluated the immunostimulatory capacity of a library aryl trehalose derivatives and evaluated the structure activity relationship of the compounds in terms of the ability of compounds to engage the Mincle receptor, induce production of innate cytokines from human and murine cells, induce a pro-Th17 cytokine profile from primary human peripheral blood mononuclear cells and demonstrated efficacy in generating antibodies in combination with a tuberculosis antigen M72 in a mouse model.
|
31809053 |
2020 |
|
Tuberculosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
Macrophage-inducible C-type lectin (Mincle) interacts with the γ-subunit of high-affinity IgE receptor (FcεRIγ) and activates Syk by recognizing its specific ligand, trehalose-6,6'-dimycolate, a glycolipid produced by Mycobacterium tuberculosis.
|
28393919 |
2017 |
|
Tuberculosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
To determine the significance of Mincle during tuberculosis (TB), we analyzed the outcome of Mtb infection in Mincle-deficient mice.
|
22784441 |
2013 |
|
Tuberculosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
C-type lectin receptor 4e (Clec4e) recognizes the cord factor of Mycobacterium tuberculosis but also senses molecular patterns released by necrotic cells and drives inflammation.
|
27587433 |
2016 |
|
Keratitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Animals and cells were randomly divided into control and A. fumigatus keratitis group, which were treated with Mincle ligand Trehalose-6,6-dibehenate (TDB), Mincle neutralizing antibody (MincleAb) or PBS before infection.
|
28888778 |
2017 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We addressed the impact of Clec4e activation on macrophage functions in vitro and on the development of atherosclerosis using low-density lipoprotein receptor-deficient (Ldlr<sup>-/-</sup>) mice in vivo.
|
27587433 |
2016 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Macrophage-inducible C-type lectin (MINCLE) is an important member of C-type lectin superfamily, which has been shown evidence for susceptibility to arthritis in animal models.
|
22932191 |
2012 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We addressed the impact of Clec4e activation on macrophage functions in vitro and on the development of atherosclerosis using low-density lipoprotein receptor-deficient (Ldlr<sup>-/-</sup>) mice in vivo.
|
27587433 |
2016 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Together these data support a role for CLRs in autoimmunity and implicate the MCL/MINCLE pathway as a potential therapeutic target in MS.
|
31725411 |
2020 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
The interaction also yielded a depression in the initiation of Mincle/Syk/IL-1β pathway.
|
27845194 |
2017 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The interaction also yielded a depression in the initiation of Mincle/Syk/IL-1β pathway.
|
27845194 |
2017 |
|
Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Mincle (macrophage-inducible C-type lectin, Clec4e) is a transmembrane pattern recognition receptor involving the innate immunity, but its role in kidney disease is still unexplored.
|
28017324 |
2017 |
|
Alcoholic Liver Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The aim was to examine the role of Mincle-SAP130 in the pathogenesis of alcoholic liver disease.
|
29355515 |
2018 |
|
Lupus Nephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The main focus of the present study is to describe the biological consequences of renal DNaseI shut-down and reduced chromatin fragmentation with a particular focus on whether exposed large chromatin fragments activate Toll like receptors and the necrosis-related Clec4e receptor in murine and human lupus nephritis.
|
22479529 |
2012 |
|
Multiple Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together these data support a role for CLRs in autoimmunity and implicate the MCL/MINCLE pathway as a potential therapeutic target in MS.
|
31725411 |
2020 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that Mincle is involved in triggering sequential processes that lead to the pathogenesis of neuropathic pain.
|
30696945 |
2019 |
|
Subarachnoid Hemorrhage
|
0.010 |
Biomarker
|
disease |
BEFREE |
Microglial macrophage-inducible C-type lectin (Mincle) receptor launches microglial innate immunity after SAH, and thereby achieves a key step of early cerebral injury in SAH.
|
27845194 |
2017 |
|
Ventricular arrhythmia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The MI rats exhibited a higher arrhythmia score after programmed electric stimulation than that treated with Mincle siRNA, suggesting that the inhibition of Mincle attenuated foetal ventricular arrhythmias post-MI.
|
30353660 |
2019 |