|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Microglial Mincle receptor in the PVN contributes to sympathetic hyperactivity in acute myocardial infarction rat.
|
30353660 |
2019 |
|
Alcoholic Liver Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The aim was to examine the role of Mincle-SAP130 in the pathogenesis of alcoholic liver disease.
|
29355515 |
2018 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We addressed the impact of Clec4e activation on macrophage functions in vitro and on the development of atherosclerosis using low-density lipoprotein receptor-deficient (Ldlr<sup>-/-</sup>) mice in vivo.
|
27587433 |
2016 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Macrophage-inducible C-type lectin (MINCLE) is an important member of C-type lectin superfamily, which has been shown evidence for susceptibility to arthritis in animal models.
|
22932191 |
2012 |
|
Asthma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
AA and NA could be differentiated by increased ATP2A3 and FPR2 in AA, decreased CLEC4E in AA, and increased IFIH1 expression in NA following anti-CD3/28 stimulation vs unstimulated (fold change).
|
30102794 |
2018 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We addressed the impact of Clec4e activation on macrophage functions in vitro and on the development of atherosclerosis using low-density lipoprotein receptor-deficient (Ldlr<sup>-/-</sup>) mice in vivo.
|
27587433 |
2016 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Together these data support a role for CLRs in autoimmunity and implicate the MCL/MINCLE pathway as a potential therapeutic target in MS.
|
31725411 |
2020 |
|
Chlamydia Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
This analysis revealed that one of these four, CLEC4E, may be upregulated in response to chlamydia infection.
|
26471184 |
2015 |
|
Chronic pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Macrophage-inducible C-type lectin (Mincle), a pattern recognition receptor, is a critical component of the innate immune system that is involved in the pathogenesis of chronic pain.
|
30312752 |
2019 |
|
Cutaneous hypersensitivity
|
0.010 |
Biomarker
|
disease |
BEFREE |
For examples, the macrophage-inducible C-type lectin (MINCLE), by sensing glycolipids released during cell-damage, promotes skin allergy and the pathogenesis of experimental autoimmune uveoretinitis.
|
29497419 |
2018 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The interaction also yielded a depression in the initiation of Mincle/Syk/IL-1β pathway.
|
27845194 |
2017 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The interaction also yielded a depression in the initiation of Mincle/Syk/IL-1β pathway.
|
27845194 |
2017 |
|
Fungal keratitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Higher levels of Mincle mRNA and protein, as well as epithelial thickness and presence of inflammatory cells in the stroma, were observed in the AF group compared to control.
|
28888778 |
2017 |
|
Fungal keratitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The mRNA expressions of Mincle in the corneas of both normal and FK patients were significantly different.
|
28141595 |
2017 |
|
HIV Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Impact of Aging and HIV Infection on the Function of the C-Type Lectin Receptor MINCLE in Monocytes.
|
30239628 |
2019 |
|
Hyperactive behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The underlying mechanism of Mincle in sympathetic hyperactivity was investigated in lipopolysaccharide (LPS)-primed naïve rats.
|
30353660 |
2019 |
|
Infection by Aspergillus fumigatus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of Mincle increases significantly during the early period of Aspergillus fumigatus infection, while expression of eight corresponding cytokines changes.
|
28141595 |
2017 |
|
Keratitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Animals and cells were randomly divided into control and A. fumigatus keratitis group, which were treated with Mincle ligand Trehalose-6,6-dibehenate (TDB), Mincle neutralizing antibody (MincleAb) or PBS before infection.
|
28888778 |
2017 |
|
Keratitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Lastly, corneal epithelium of 54 patients with Aspergillus fumigatus keratitis and 13 ocular trauma patients were collected to detect expression of Mincle by real-time RT-PCR, and 12 FK and 10 ocular trauma paraffin samples were collected to confirm expression of Mincle by immunohistochemistry.
|
28141595 |
2017 |
|
Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Mincle (macrophage-inducible C-type lectin, Clec4e) is a transmembrane pattern recognition receptor involving the innate immunity, but its role in kidney disease is still unexplored.
|
28017324 |
2017 |
|
Kidney Failure, Acute
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the early stage of acute kidney injury, M1 macrophages are proinflammatory and destructive.In this study, Lv et al. reveal that Mincle (macrophage-inducible C-type lectin, Clec4e) is expressed on M1 macrophages in acute kidney injury, and the kidney is protected in a murine model of cisplatin-induced renal injury by inhibiting Mincle expression on macrophages.
|
28202166 |
2017 |
|
Lung diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Blood gene expression profiling detects silica exposure and toxicity.
|
21602193 |
2011 |
|
Lupus Nephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The main focus of the present study is to describe the biological consequences of renal DNaseI shut-down and reduced chromatin fragmentation with a particular focus on whether exposed large chromatin fragments activate Toll like receptors and the necrosis-related Clec4e receptor in murine and human lupus nephritis.
|
22479529 |
2012 |
|
Mechanical Allodynia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Most Mincle immunoreactivity was localized within the grey matter and the dorsal and ventral horns of the lumbar spinal cord in naïve rats.A single intrathecal (i.t.) injection of trehalose-6,6-dibehenate (TDB), a Mincle ligand, induced mechanical allodynia.
|
30312752 |
2019 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
The interaction also yielded a depression in the initiation of Mincle/Syk/IL-1β pathway.
|
27845194 |
2017 |