|
Congenital heart disease
|
0.200 |
Biomarker
|
group |
BEFREE |
The detection rate was 10/48 (20.8 per cent) in the presence of VSD, ASD2 or combined ASD2 + VSD, the detection rate was 29/39 (74.3 per cent) in the presence of other forms of congenital heart disease.
|
9742568 |
1998 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We conclude that haploinsufficiency at the GATA4 locus is often seen in patients with del(8)(p23.1) and congenital heart disease.
|
10096597 |
1999 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In support of this, mutations of gene for GATA-4 or for its cofactors have been associated with human congenital heart disease.
|
15249177 |
2004 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Screening of 99 Danish patients with congenital heart disease for GATA4 mutations.
|
17253934 |
2006 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease.
|
17352393 |
2007 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
To gain insights into congenital heart disease (CHD), we have been analyzing cardiac-specific transcription factor genes, including GATA4, which encodes a zinc finger transcription factor.
|
17592645 |
2007 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We then asked if GATA4 mutation occurs in humans with these forms of congenital heart disease (CHD).
|
17643447 |
2007 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
GATA4 sequence variants in patients with congenital heart disease.
|
18055909 |
2007 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
GATA4 mutations in 486 Chinese patients with congenital heart disease.
|
18672102 |
2009 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
GATA4 and NKX2.5 gene analysis in Chinese Uygur patients with congenital heart disease.
|
19302747 |
2009 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Multiplex ligation-dependent probe amplification analysis of GATA4 gene copy number variations in patients with isolated congenital heart disease.
|
20592452 |
2010 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Mutations in GATA4 have been related to human congenital heart diseases (CHDs) in several studies, whereas mutations in GATA6 have only recently been reported in patients with persistent truncus arteriosus.
|
20631719 |
2010 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Mutations of the GATA4 and NKX2.5 genes in Chinese pediatric patients with non-familial congenital heart disease.
|
21110066 |
2010 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
GATA4 specific nonsynonymous single-nucleotide polymorphisms in congenital heart disease patients of Mysore, India.
|
21631294 |
2011 |
|
Congenital heart disease
|
0.200 |
Biomarker
|
group |
BEFREE |
The human transcription factors (TFs) GATA4, NKX2.5 and TBX5 form part of the core network necessary to build a human heart and are involved in Congenital Heart Diseases (CHDs).
|
21990232 |
2012 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo.
|
22589735 |
2012 |
|
Congenital heart disease
|
0.200 |
Biomarker
|
group |
BEFREE |
Mutations in cardiac transcription factor genes, such as GATA-4, NKX2-5 and TBX5 genes, have been associated to the patients with familial and isolated congenital heart disease (CHD).
|
22885181 |
2012 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
These results suggest that genomic GATA4 and TFAP2B missense mutations may be associated with nonfamilial congenital heart disease with diverse clinical phenotypes in patients with congenital heart disease from southern China.
|
22959235 |
2013 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Identification of functional mutations in GATA4 in patients with congenital heart disease.
|
23626780 |
2013 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Genetic mutations in GATA4, a transcriptional factor, have been found to cause congenital heart diseases.
|
23745586 |
2013 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The cardiac transcription factor GATA4 is essential for cardiac development, and mutations in this gene have been implicated in a wide variety of congenital heart diseases in both animal models and humans.
|
24041700 |
2013 |
|
Congenital heart disease
|
0.200 |
Biomarker
|
group |
BEFREE |
GATA4 transgenic mice as an in vivo model of congenital heart disease.
|
25873328 |
2015 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
c.620C>T mutation in GATA4 is associated with congenital heart disease in South India.
|
25928801 |
2015 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Variants in the GATA4 gene have been implicated in several congenital heart diseases (CHD), such as the tetralogy of Fallot (ToF), atrial septal defect (ASD), ventricular septal defect (VSD), atrioventricular septal defect (AVSD), and dilated cardiomyopathy (DCM).
|
26376067 |
2016 |
|
Congenital heart disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Common variants in 3'UTR of the GATA4 gene jointly interact, affecting the congenital heart disease susceptibility, probably by altering microRNA posttranscriptional regulation.
|
27118528 |
2016 |