GBE1, 1,4-alpha-glucan branching enzyme 1, 2632

N. diseases: 102; N. variants: 48
Disease: Malignant Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 Biomarker group BEFREE GBE1 blockade promotes the secretion of CCL5 and CXCL10 to recruit CD8<sup>+</sup> T lymphocytes to the tumor microenvironment via the IFN-I/STING signaling pathway, accompanied by upregulation of PD-L1 in LUAD cells, suggesting that GBE1 could be a promising target for achieving tumor regression through cancer immunotherapy in LUAD. 31221150 2019