Abnormal C-peptide level
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Abnormal oral glucose tolerance
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Abnormality of the autonomic nervous system
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Abnormality of the immune system
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Acute Chest Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among 36 CR and 36 non-CR acute coronary syndrome (ACS) patients, the platelet functions were evaluated by VerifyNow P2Y12 assay (turbidimetric-based optical detection) and DNA methylation levels on two fragments of the CGI from the GCK were investigated through bisulfite pyrosequencing methods.
|
31605429 |
2020 |
Acute Coronary Syndrome
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Among 36 CR and 36 non-CR acute coronary syndrome (ACS) patients, the platelet functions were evaluated by VerifyNow P2Y12 assay (turbidimetric-based optical detection) and DNA methylation levels on two fragments of the CGI from the GCK were investigated through bisulfite pyrosequencing methods.
|
31605429 |
2020 |
Adult Liver Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In addition, GLK overexpression in cancer tissues is correlated with cancer recurrence of human lung cancer and liver cancer; the predictive power of GLK overexpression for cancer recurrence is higher than that of pathologic stage.
|
31640697 |
2019 |
Adult Liver Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The up-regulation of expression of hepatic genes related to liver steatosis (CPT1A, FASN, LEPR, RXRA, IGFBP1, PPARGC1A and SLC2A4) was detected in our rhesus model, as was the down-regulation of such genes (CYP7A1, HMGCR, GCK and PNPLA3) and the up-regulation of expression of hepatic genes related to liver cancer (E2F1, OPCML, FZD7, IGFBP1 and LEF1).
|
26442469 |
2015 |
Adult-Onset Still Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Moreover, GLK levels are increased in T cells from patients with SLE, rheumatoid arthritis, or adult-onset Still's disease; the percentages of GLK-overexpression T cells are correlated with the disease activity.
|
26791862 |
2016 |
Adult-Onset Still Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
The disease activity scores were positively correlated with the frequencies of circulating GLK-expressing T-cells (r = 0.599, P <0.005) and the levels of GLK proteins (r = 0.435, P <0.05) or GLK transcripts (r = 0.452, P <0.05) in patients with adult-onset Still's disease.
|
22867055 |
2012 |
Agenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A panel of pancreas development genes, including GCK, Kir6.2, PTF1A, PDX-1, HNF-1A, NgN3, SOX17, SOX7, SOX9, INS, HNF1-B and SUR1 plus the GATA4 gene, were screened for characterization of pancreatic agenesis and cardiac defect.
|
20854389 |
2010 |
Alloxan Diabetes
|
0.300 |
Biomarker
|
disease |
CTD_human |
Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes.
|
16123366 |
2005 |
Anteverted nostril
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Apraxias
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
GCK-MODY patients are typically characterized by a moderate fasting hyperglycemia; however, little is known about atherosclerosis and intermediate-related phenotypes in these subjects.
|
25501962 |
2015 |
Arthrogryposis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Ataxia
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
GCK-MODY patients are typically characterized by a moderate fasting hyperglycemia; however, little is known about atherosclerosis and intermediate-related phenotypes in these subjects.
|
25501962 |
2015 |
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
T-cell-mediated immune responses and Th17-mediated experimental autoimmune diseases are enhanced in HPK1 knockout mice but ameliorated in GLK knockout mice.
|
26791862 |
2016 |
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
GLK overexpression in T cells contributes to the pathogenesis of RA, indicating that GLK is a novel biomarker for autoimmune disease severity and a potential therapeutic target for RA.
|
23817999 |
2013 |
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease.
|
30214937 |
2018 |
Autoimmune Diseases
|
0.040 |
AlteredExpression
|
group |
BEFREE |
The pathogenic mechanism of autoimmune disease by GLK overexpression was unraveled by characterizing T-cell-specific GLK transgenic mice and using biochemical analyses.
|
31640697 |
2019 |
Beta-cell dysfunction
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Bilateral ptosis
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Birth Weight
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.
|
29309628 |
2018 |