|
Hypoglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The study presented a simpler and more reliable way in studying the properties of glucokinase and its effectors, providing guidelines of effector developments for hyperglycemia and hypoglycemia treatment.
|
31011989 |
2019 |
|
Hypoglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The clinical characteristics of patients with GK-activating mutations or GK regulatory protein (GKRP) loss-of-function mutations suggest that a hepatoselective GK activator (GKA) that does not activate GK in β cells or affect the GK-GKRP interaction may reduce hyperglycemia in patients with type 2 diabetes while limiting hypoglycemia and liver-associated adverse effects.
|
30651321 |
2019 |
|
Hypoglycemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Consistent with this, glucagon responses to hypoglycemia were also increased in I366F mice with mutated glucokinase and in streptozotocin-treated β-cell ablated diabetic I366F mice.
|
30146176 |
2018 |
|
Hypoglycemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As one form of congenital hyperinsulinism (CHI), activating mutations of GCK result in a decreased threshold for glucose-stimulated insulin secretion and hypoglycemia.
|
29044608 |
2018 |
|
Hypoglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia.
|
28390958 |
2017 |
|
Hypoglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A one-time intramuscular administration of adeno-associated viral vectors of serotype 1 encoding for glucokinase and insulin in diabetic dogs resulted in normalization of fasting glycemia, accelerated disposal of glucose after oral challenge, and no episodes of hypoglycemia during exercise for >4 years after gene transfer.
|
23378612 |
2013 |
|
Hypoglycemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The unique role of glucokinase in human glucose physiology is illustrated by the fact that genetic mutations in glucokinase can either cause hyperglycaemia or hypoglycaemia.
|
20878480 |
2010 |
|
Hypoglycemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A growing number of heterozygous activating GCK mutations that cause hypoglycemia have also been reported.
|
19790256 |
2009 |
|
Hypoglycemia
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Activating mutations in the human glucokinase gene revealed by genetic selection.
|
19146401 |
2009 |
|
Hypoglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results confirm the potency of glucokinase as the pancreatic beta-cell glucose sensor, and they demonstrate that responsiveness to diazoxide varies with genotype in glucokinase hyperinsulinism resulting in hypoglycemia, which can be more difficult to control than previously believed.
|
19336674 |
2009 |
|
Hypoglycemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutational analysis of the GCK-gene should be performed in all individuals with unclear episodes of hypoglycemia even without documented hyperinsulinism during hypoglycemia.
|
19053014 |
2009 |
|
Hypoglycemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A novel GCK mutation (G68V) co-segregating with hypoglycaemia was identified in eight family members.
|
17976205 |
2007 |
|
Hypoglycemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We report two novel GCK mutations (T65I and W99R) that have arisen de novo in two families with familial hypoglycemia.
|
12941786 |
2003 |
|
Hypoglycemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several heterozygous activating GCK mutations that cause hypoglycemia have also been reported.
|
14517946 |
2003 |
|
Hypoglycemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to assess functional consequences of glucokinase mutations, counterregulatory hormones secretion and glucose production (6,6(- 2) H glucose) were monitored during an hyperinsulinemic clamp at about 2.4 pmol.kg(- 1).min(- 1) insulin with progressive hypoglycemia in 7 maturity onset diabetes of the young (MODY) type 2 patients, 5 patients with type 2 diabetes, and 13 healthy subjects.
|
11119017 |
2000 |
|
Hypoglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutations in human glucokinase are implicated in the development of diabetes and hypoglycemia.
|
10480597 |
1999 |
|
Hypoglycemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis.
|
10525657 |
1999 |