GCK, glucokinase, 2645

N. diseases: 210; N. variants: 182
Disease: Steatohepatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.030 AlteredExpression disease BEFREE Genetic ablation of SIN3A abolishes nutrient regulation of glucokinase without affecting other FOXO1 target genes and lowers glycemia without concurrent steatosis. 29056338 2017
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.030 AlteredExpression disease BEFREE The up-regulation of expression of hepatic genes related to liver steatosis (CPT1A, FASN, LEPR, RXRA, IGFBP1, PPARGC1A and SLC2A4) was detected in our rhesus model, as was the down-regulation of such genes (CYP7A1, HMGCR, GCK and PNPLA3) and the up-regulation of expression of hepatic genes related to liver cancer (E2F1, OPCML, FZD7, IGFBP1 and LEF1). 26442469 2015
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.030 AlteredExpression disease BEFREE This suggests that increased GCK activity may induce fatty liver and its metabolic and hepatic consequences in humans. 21490074 2011