|
Malignant neoplasm of prostate
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
A key glycosyltransferase, GCNT1, was consistently over-expressed in several prostate cancer gene expression datasets.
|
24854630 |
2014 |
|
Prostatic Neoplasms
|
0.320 |
GeneticVariation
|
group |
LHGDN |
An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer.
|
15882971 |
2005 |
|
Prostatic Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer.
|
15882971 |
2005 |
|
Prostatic Neoplasms
|
0.320 |
Biomarker
|
group |
LHGDN |
Expression of core 2 beta1,6-N-acetylglucosaminyltransferase facilitates prostate cancer progression.
|
15932919 |
2005 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
CTD_human |
These results demonstrate that C2GnT A/G polymorphism is associated with the susceptibility to prostate cancer in a Japanese population.
|
15882971 |
2005 |
|
Malignant neoplasm of prostate
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
These results demonstrate that C2GnT A/G polymorphism is associated with the susceptibility to prostate cancer in a Japanese population.
|
15882971 |
2005 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue.
|
7560067 |
1995 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
However, O-glycan synthesis enzyme core 2 beta 1,6 N-acetylglucosaminyltransferase (GCNT3/C2GnT-2) is overexpressed in Kras-driven mouse and human cancer, and inhibition of GCNT3 has been shown to disrupt mucin synthesis.
|
28039261 |
2017 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
The I-branching β-1,6-N-acetylglucosaminyltransferase, converting the straight i to branched I histo-blood group antigens, reportedly could influence the migration, invasion, and metastasis of solid tumors.
|
28337749 |
2017 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
However, O-glycan synthesis enzyme core 2 beta 1,6 N-acetylglucosaminyltransferase (GCNT3/C2GnT-2) is overexpressed in Kras-driven mouse and human cancer, and inhibition of GCNT3 has been shown to disrupt mucin synthesis.
|
28039261 |
2017 |
|
Prostate carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
A key glycosyltransferase, GCNT1, was consistently over-expressed in several prostate cancer gene expression datasets.
|
24854630 |
2014 |
|
Carcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Our findings indicate that C2GnT1 gene expression and the resulting C2-O-sLe(X) carbohydrates produced mediate the adhesive and invasive behaviors of human carcinomas which may influence their metastatic potential.
|
21283832 |
2011 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Significantly, we observed a greater than 15-fold increase in C2GnT1 mRNA levels in colorectal adenocarcinomas compared to normal colorectal tissues.
|
19267921 |
2009 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The expression of core 2 beta1,6-N-acetylglucosaminyltransferase-1 (C2GnT) is associated with development and progression of malignancy.
|
15882971 |
2005 |
|
Prostate carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These results demonstrate that C2GnT A/G polymorphism is associated with the susceptibility to prostate cancer in a Japanese population.
|
15882971 |
2005 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The expression of core 2 beta1,6-N-acetylglucosaminyltransferase-1 (C2GnT) is associated with development and progression of malignancy.
|
15882971 |
2005 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
These results indicate that C2GnT mRNA detected by in situ hybridization reflects the malignant potentials of pulmonary adenocarcinoma, because lymph node metastasis is the most affecting factor to the patients' prognosis.
|
11280791 |
2001 |
|
Carcinoma
|
0.020 |
Biomarker
|
group |
BEFREE |
These findings suggest that C2GnT in combination with alpha1,3-Fuc-T contribute to the selectin-mediated metastasis in oral cavity carcinomas.
|
11552947 |
2001 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
These findings suggest that C2GnT in combination with alpha1,3-Fuc-T contribute to the selectin-mediated metastasis in oral cavity carcinomas.
|
11552947 |
2001 |
|
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Silencing of C2GNT1 expression in NB cells diminished expression of Lewis glycans, decreased the E- and P-selectin binding, and reduced cell adhesion, migration and proliferation <i>in vitro</i>.
|
30344930 |
2018 |
|
Central neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Silencing of C2GNT1 expression in NB cells diminished expression of Lewis glycans, decreased the E- and P-selectin binding, and reduced cell adhesion, migration and proliferation <i>in vitro</i>.
|
30344930 |
2018 |
|
Childhood Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Silencing of C2GNT1 expression in NB cells diminished expression of Lewis glycans, decreased the E- and P-selectin binding, and reduced cell adhesion, migration and proliferation <i>in vitro</i>.
|
30344930 |
2018 |
|
Solid Neoplasm
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The I-branching β-1,6-N-acetylglucosaminyltransferase, converting the straight i to branched I histo-blood group antigens, reportedly could influence the migration, invasion, and metastasis of solid tumors.
|
28337749 |
2017 |
|
Diphtheria
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By applying the "toxin receptor mediated cell knockout" method under the control of the S3 segment-specific promoter/enhancer, Gsl5, which drives core 2 β-1,6-N-acetylglucosaminyltransferase gene expression, we established a transgenic mouse line expressing the human diphtheria toxin (DT) receptor only in the S3 segment.
|
21431867 |
2012 |