|
Abdominal Infection
|
0.010 |
Biomarker
|
group |
BEFREE |
This new guideline from the AST IDCOP reviews intra-abdominal infections (IAIs), which cause substantial morbidity and mortality among abdominal SOT recipients.
|
31102546 |
2019 |
|
Abnormality of metabolism/homeostasis
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of the thorax
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Acute hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Arctigenin remarkably reduced the congestion and necroinflammation of livers, and improved hepatic function (ALT and AST) in ConA-induced acute hepatitis in vivo.
|
29579707 |
2018 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Leukocytes, glucose, aspartate aminotransferase (AST (SGOT)), alanine aminotransferase (ALT (SGPT)), alkaline phosphatase (ALP), total and direct bilirubin levels were significantly higher in the AP group (<i>p</i> < 0.05, all).
|
29593801 |
2018 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Occupational exposure plays an important role in causing ALT abnormalities and fatty liver among oil workers, but not a risk factor of cirrhosis, AST abnormalities and liver cancer.
|
30296610 |
2018 |
|
Adult Myelodysplastic Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
NUP98-NSD3 fusion gene in radiation-associated myelodysplastic syndrome with t(8;11)(p11;p15) and expression pattern of NSD family genes.
|
19380029 |
2009 |
|
Alcohol abuse
|
0.010 |
Biomarker
|
disease |
BEFREE |
In alcoholics, compared to the controls, we found: a significant increase in serum: AST (p = 0.0014), ALT (p = 0.0071), AST/ALT ratio (p < 0.000); significantly lower plasma free carnitine (FC) (p = 0.0316) and total carnitine (TC) (p = 0.0349); and a significant negative correlation between FC (r = -0.6200; R<sup>2</sup> = 0.3844; p = 0.0007), TC (r = -0.4365; R<sup>2</sup> = 0.1905; p = 0.0258), and time of alcohol dependence, suggesting carnitine as an indirect marker of alcohol abuse.
|
31029632 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.310 |
Biomarker
|
disease |
PSYGENET |
In an attempt to explain the well-known increase of serum mitochondrial AST-to-total AST ratio in chronic alcoholism (which is due to a specific increase of the mitochondrial isoenzyme), we analyzed: (a) liver and serum AST, ALT and glutamate dehydrogenase activities in 23 active drinkers with minimal liver changes, 11 alcoholic patients with cirrhosis who had stopped drinking, 18 nonalcoholic patients with viral chronic hepatitis and 11 subjects with normal livers; and (b) the expression of messenger RNAs for AST isoenzymes in the corresponding liver samples.
|
1916663 |
1991 |
|
Alcoholic Intoxication, Chronic
|
0.310 |
Biomarker
|
disease |
BEFREE |
In alcoholics, compared to the controls, we found: a significant increase in serum: AST (p = 0.0014), ALT (p = 0.0071), AST/ALT ratio (p < 0.000); significantly lower plasma free carnitine (FC) (p = 0.0316) and total carnitine (TC) (p = 0.0349); and a significant negative correlation between FC (r = -0.6200; R<sup>2</sup> = 0.3844; p = 0.0007), TC (r = -0.4365; R<sup>2</sup> = 0.1905; p = 0.0258), and time of alcohol dependence, suggesting carnitine as an indirect marker of alcohol abuse.
|
31029632 |
2019 |
|
Allergic asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The overall results confirmed that AST with TWDS prescription had a significant protective effect against OVA-induced allergic asthma in guinea pig.
|
30668368 |
2019 |
|
AMELOGENESIS IMPERFECTA, HYPOPLASTIC/HYPOMATURATION, X-LINKED 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, higher serum ALT, AST levels and more common cirrhosis were observed in AIH-1 patients with T allele (CT/TT) than those with CC genotype.
|
28448618 |
2017 |
|
Amyotrophic Lateral Sclerosis, Sporadic
|
0.010 |
Biomarker
|
disease |
BEFREE |
To further verify the association between the NSD function target genes and sALS, we preformed a two-stage case-control study based on 500 sALS patients and 500 controls of Chinese Han populations from mainland.
|
27052956 |
2017 |
|
Anemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
22 participants with SF > 1,000 μg/L had significantly higher median TS, ALT, and AST, and prevalences of anemia and transfusion > 10 units; and lower median platelets.
|
28809726 |
2018 |
|
Anemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Subjects with MTHFR polymorphism for A1298C (AC, CC) had significantly higher MTX levels at 48 h (p = 0.02), and had more grade III/IV anemia (p = 0.02), thrombocytopenia (p = 0.0001), elevated AST levels (p = 0.04) and frequent febrile neutropenic episodes (p = 0.004).
|
19391036 |
2009 |
|
Anemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
DLTs at 431 mg/m(2) were grade 3 bilirubin (n = 1), AST (n = 1), anemia (n = 1), nausea (n = 1), vomiting (n = 1), and myalgias (n = 1).No tumor responses were seen.
|
15718306 |
2005 |
|
Anemia, Sickle Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
A significant number of our patients with NT-SCD had high LIC, high SF and elevated liver enzymes (ALT and AST).
|
28698780 |
2017 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Primary tumor location, diameter, elevated ALT and AST, and increased CA19-9 are independent risk factors of synchronous liver metastasis in PDAC patients.
|
28673297 |
2017 |
|
Anteverted nostril
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
AST-120 could, therefore, be used as a therapeutic to treat atherosclerosis in patients with CKD.
|
31666542 |
2019 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Recently, AST-120 has been reported to reduce the progression of atherosclerosis as well.
|
17088950 |
2007 |
|
Ascites
|
0.120 |
Biomarker
|
phenotype |
BEFREE |
Univariate analysis of patients taking β-blockers showed an association of PVT with grade of esophageal varices (p < 0.01), CP class (p < 0.02), AST (p < 0.03), ALT and albumin (p < 0.02), PLT count and PLT/LD (p < 0.03), longitudinal diameter of the spleen (p < 0.005), ascites (p < 0.05), portal vein (p < 0.0001) and NSBB (OR 8.1; 95% CI 1.7-38.8).
|
30107378 |
2018 |
|
Ascites
|
0.120 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Ascites
|
0.120 |
Biomarker
|
phenotype |
BEFREE |
GGT and AST showed discrimination between abstinence and recent drinking in patients with cirrhosis, including those without ascites, when appropriate (and for GGT, sex-specific) limits were used.
|
29277282 |
2018 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Parents were subdivided into four phenotypes on the basis of skin sensitization (SPT+ or SPT-) and asthma status (AST+ or AST-) and offspring were subdivided into three age groups: 3-8, 9-14 and 15-20 years.
|
17537161 |
2007 |