|
Hepatolenticular Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum biochemical diagnostic ratios predicting WD-ALF (ALP: bilirubin and AST:ALT) were determined in these patients.
|
31838773 |
2020 |
|
Pancytopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Laboratory studies were remarkable for pancytopenia (most notably a WBC of 0.4 × 10<sup>3</sup> cells/mm<sup>3</sup>, with an absolute neutrophil count (ANC) of 0 × 10<sup>3</sup> cells/mm<sup>3</sup>) and transaminase elevation (AST 268 IU/L, ALT 89 IU/L).
|
31701853 |
2020 |
|
Medium-chain acyl-coenzyme A dehydrogenase deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Children with MCAD deficiency had normal growth. p.Lys329Glu homozygotes had higher NBS C8-carnitine (23.4 ± 19.6 vs. 6.6 ± 3.0 μmol/L) and lifetime plasma C8-carnitine levels (6.2 ± 5 vs. 3.6 ± 1.9 μmol/L) compared to patients with at least one other pathogenic variant (p < .001 for both) and higher transaminases compared to compound heterozygotes (ALT 41.9 ± 6.2 vs. 31.5 ± 3.7 U/L, AST 63.9 ± 5.8 vs. 45.7 ± 1.8 U/L, p < .05 for both).
|
31836396 |
2020 |
|
Inattention
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Children's performance on the AST was meaningfully related to hyperactivity-inattention, externalizing behavior and overall level of childhood psychopathology.
|
31535948 |
2020 |
|
Hyperactive behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Children's performance on the AST was meaningfully related to hyperactivity-inattention, externalizing behavior and overall level of childhood psychopathology.
|
31535948 |
2020 |
|
Nonalcoholic Steatohepatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In patients with nonalcoholic steatohepatitis (NASH), PNPLA3 GG compared to CC was associated with higher AST levels [38.4±25.3 versus 36.7±40.1IU/L, p=0.0395)] and with the presence of liver fibrosis (≥F2 fibrosis, p=0.0272).
|
31054980 |
2020 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Objectives:</b> To validate the usefulness of a hepatic fibrosis scoring system fibrosis-4 (FIB-4) index to diagnose liver diseases in rheumatoid arthritis (RA) patients treated with methotrexate (MTX).<b>Methods:</b> The FIB-4 index (age(years) × AST(U/L)/platelet (PLT) (10<sup>9</sup>/L) × √ALT(U/L)), proposed as a predictor for liver fibrosis in HIV/HCV coinfection, was evaluated in this study.
|
30379089 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A 10.0% tumor shrinkage in the SLD indicated an indicative efficacy evaluation threshold for NSCLC patients treated with chemotherapy plus targeted agents.
|
31355220 |
2019 |
|
Cataplexy
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that the SLD functions to engage arousal-motor synchrony during both wakefulness and REM sleep, and we propose that pathological recruitment of SLD neurons could underlie cataplexy in narcolepsy.
|
31679942 |
2019 |
|
Congenital chromosomal disease
|
0.010 |
Biomarker
|
group |
BEFREE |
<b>Materials and methods:</b> The effect of five days oral administration of TiO<sub>2</sub>NPs (21 and 80 nm) with different doses (50, 250 and 500 mg/kg body weight) was assessed in mice via measurement of oxidative stress markers; glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and nitric oxide (NO), liver function indices; aspartate and alanine aminotransferases (AST and ALT), chromosomal aberrations and liver histopathological pattern.
|
31099265 |
2019 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
With regard to the antitumor activity of Co-SLD, inhibited cell growth and migration capability were outstandingly observed in oral squamous cell carcinoma treated with 10 and 20 μM Co-SLD, which could be mainly attributed to the Co-SLD-elicited mitochondrial damage as marked by the depression of mitochondrial membrane potential, ROS accumulation and ATP depletion.
|
31062618 |
2019 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
With regard to the antitumor activity of Co-SLD, inhibited cell growth and migration capability were outstandingly observed in oral squamous cell carcinoma treated with 10 and 20 μM Co-SLD, which could be mainly attributed to the Co-SLD-elicited mitochondrial damage as marked by the depression of mitochondrial membrane potential, ROS accumulation and ATP depletion.
|
31062618 |
2019 |
|
Dermatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We report on the case of two siblings affected by recurrent attacks of fever, oral aphthous stomatitis, abdominal pain, arthritis, undefined dermatitis at the hands, associated with increased AST, ALT, C-reactive protein, erythrocyte sedimentation rate, serum amyloid A, leucocytosis with neutrophilia.Infectious diseases were excluded.
|
31443670 |
2019 |
|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Predictive Factors for Efficacy of AST-120 Treatment in Diabetic Nephropathy: a Prospective Single-Arm, Open-Label, Multi-Center Study.
|
31001934 |
2019 |
|
Disseminated Intravascular Coagulation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Abbreviations: AML: acute myeloid leukemia; APL: acute promyelocytic leukemia; WBC: white blood cell; RBC: red blood cell; Hb: hemoglobin; PT: prothrombin time; TT: thrombin time; APTT: activated partial thromboplastin time; TP: total protein; ALB: albumin; AST: aspartate transaminase; ALT: alanine aminotransferase; LDH: lactate dehydrogenase; ATRA: all-trans retinoic acid; ICH: intracranial hemorrhage; DIC: disseminated intravascular coagulation.
|
30453810 |
2019 |
|
IGA Glomerulonephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared to patients with IgAN-NSD, those with IgAN-SD had significantly lower mean serum protein (6.4 g/dL vs. 6.7 g/dL; p = 0.02), albumin (3.7 g/dL vs. 3.9 g/dL; p = 0.02), and complement (C3) (94 mg/dL vs. 103 mg/dL; p = 0.02) levels.
|
30785896 |
2019 |
|
Heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To determine whether blood levels of the uremic toxin indoxyl sulfate (IS) increase in HF and whether AST-120 can reduce those levels and improve HF.
|
30903544 |
2019 |
|
Hypercholesterolemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared to normal control diet (CD), FATZO mice fed with WDF were heavier with higher body fat measured by qNMR, hypercholesterolemia and had progressive elevations in AST (~ 6 fold), ALT (~ 6 fold), liver over body weight (~ 2 fold) and liver triglyceride (TG) content (1.4-2.9 fold).
|
30885145 |
2019 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In addition, the hepatoprotective effect of 20E was demonstrated by decreased plasma concentrations of AST, ALT and of hepatic malondialdehyde.Our results suggest that <i>G. tarabuli</i> represents a good model to study diet-induced metabolic disorders and hepatic dysfunctions.
|
31190566 |
2019 |
|
Narcolepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that the SLD functions to engage arousal-motor synchrony during both wakefulness and REM sleep, and we propose that pathological recruitment of SLD neurons could underlie cataplexy in narcolepsy.
|
31679942 |
2019 |
|
Nodule
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
When samples were grouped according to the serum level of AKR1B10 (≥232.7pg/ml), serum AKR1B10 positively correlated to serum AFP (χ<sup>2</sup>=6.295, P=0.012), ALT (χ<sup>2</sup>=18.803, P=0.000), AST (χ<sup>2</sup>=33.421, P=0.000), tumor nodule number (χ<sup>2</sup>=6.777, P=0.009), cirrhosis (χ<sup>2</sup>=43.458, P=0.000), and tumor size (χ<sup>2</sup>=6.042, P=0.014) in the Chi-square test.
|
31495535 |
2019 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, rats subjected to long-term SheaFlex75 ingestion showed normal biochemical profiles (AST, BUN and total cholesterol) and presented relatively lower triglycerides (TGs) and body weights than the OA-control rats, which suggested the safety of prolonged use of this oil extract.
|
31002699 |
2019 |
|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These guidelines from the AST Infectious Diseases Community of Practice review the diagnosis and management of pneumonia in the post-transplant period.
|
30900275 |
2019 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
Astragaloside IV (AST-IV) is a primary bioactive compound of Radix Astragali, which is widely used in traditional Chinese medicine to treat stroke.
|
30708047 |
2019 |
|
Vitamin D Deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Multivariate logistic regression models, adjusted for age, gender, BMI, sampling season, glucose, total cholesterol, triglycerides, HOMA-IR, hs-CRP, ALT, AST, and elevated VAT, revealed an association between FL and vitamin D (VD) insufficiency (RM 1.61 [0.99-2.61]) and with VDD (RM 1.68 [1.02-2.77]); however, statistical significance was lost when including caloric consumption and physical activity in the model.
|
29735791 |
2019 |