|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We observed higher frequency of <i>KIR A</i> homozygosity among 745 healthy Chinese Southern Han than 836 adult patients representing three types of leukemia: ALL (OR = 0.68, 95% CI = 0.52-0.89, <i>p</i> = 0.004), AML (OR = 0.76, 95% CI = 0.59-0.98, <i>p</i> = 0.034), and CML (OR = 0.72 95% CI = 0.51-1.0, ns).
|
31379844 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular identification of this ligand may lead to improved KIR-HLA mismatching in hematopoietic stem cell transplantation therapy for leukemia and new, more specific NK cell-based cancer therapies.
|
28202613 |
2017 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We prospectively analysed the human leucocyte antigen typing of donor-recipient pairs and the killer cell immunoglobulin-like receptor (KIR) typing of donors for 180 leukaemia patients to assess the predictive roles of licensed NK cells on CMV reactivation post-T-cell-replete haploidentical stem cell transplantation.
|
28466469 |
2017 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HLA expression on leukemia cells-upregulated in the post-HCT environment-signals for NK cell inhibition via inhibitory killer immunoglobulin-like (KIR) receptors and interrupts their antitumor activity.
|
28520526 |
2017 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, patients receiving hematopoietic stem cell transplants for leukemia may do better if their donor has more activating KIR genes (i.e., KIR haplotype-B).
|
27695964 |
2016 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have studied the different haplotypic combinations of 17 KIR genes in 300 healthy individuals and 43 patients with haematological malignancies (25 with leukaemia and 18 with lymphomas).
|
26495028 |
2015 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The increased inhibitory KIR expression by proliferating CMV-specific CD8 T cells suggests regulatory interactions between HLA-C and KIR might promote Graft-versus-Leukemia effects following transplantation.
|
26416275 |
2015 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data support the use of a triple immunotherapy approach, including an antibody directed against tumor-associated antigen, KIR-mismatched NK cell transplantation, and inhibitory KIR blockade, for the treatment of NK cell-resistant MLL-rearranged leukemias.
|
23014531 |
2012 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have shown associations between KIR genes, their ligands and either protection or susceptibility to leukemias or virally associated solid tumors.
|
21479698 |
2012 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the association of KIR gene polymorphisms with subtypes of leukemia, we carried out the present study on 263 patients with leukemia and 239 healthy controls by means of polymerase chain reaction-sequence-specific primer and analysis, and then all data were analyzed by Logistic regression method.
|
19450876 |
2010 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of our study was to evaluate the effect of KIR genes and KIR ligands on leukemia free survival (LFS) and relapse rate in a well-defined, homogeneous group of CML patients phase upon HLA identical sibling SCT.
|
18555529 |
2008 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, the association of KIR genes with acute graft-vs-host disease (GVHD) was investigated in 44 pairs of leukemia patients and their unrelated donors for hematopoietic stem cell transplantation (HSCT).
|
17445182 |
2007 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Low number of donor activating killer immunoglobulin-like receptors (KIR) genes but not KIR-ligand mismatch prevents relapse and improves disease-free survival in leukemia patients after in vivo T-cell depleted unrelated stem cell transplantation.
|
17060849 |
2006 |