Disease: Multiple Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE We investigated association between HLA class I and class II alleles and haplotypes, and KIR loci and their HLA class I ligands, with multiple sclerosis (MS) in 412 European American MS patients and 419 ethnically matched controls, using next-generation sequencing. 29307888 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE By calculating the total HLA and KIR entropy ratio in each subject, it was possible to determine the individual risk of developing MS, particularly RRMS. 31846493 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE Here, we review and discuss the decades long research on the influence of genetic variation at the MHC locus and the role of immunogenetic killer cell immunoglobulin-like receptor (KIR) loci in neurological diseases, including multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis. 29159928 2018
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE Our study, the first investigation of KIR and MS in African Americans, confirms and refines previous findings in a European cohort. 26866467 2016
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE However, studies to-date of KIR in MS have been few and limited to very low resolution genotyping. 26142251 2015
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE We investigated the influence of KIR genes on MS susceptibility in 447 MS Portuguese patients, and also whether genetic interactions between specific KIR genes and their HLA class I ligands could contribute to the pathogenesis of MS. We observed a negative association between the activating KIR2DS1 gene and MS (adjusted OR=0.450, p=0.030) independently from the presence of HLA-DRB1*15 allele. 24529855 2014
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE We investigated the association of HLA alleles and KIR ligands according to OCB status in MS patients (n=3876). 25037176 2014
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE Here we determined the influence of KIR genes and their HLA class I ligands on susceptibility to MS and on the response to interferon-beta treatment in a Spanish population. 21665278 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. 20826009 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE We investigated the HLA class I alleles defined by their KIR binding motifs and the KIR genes to evaluate whether these genes could influence MS susceptibility or severity, alone or in combination. 19630074 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE The relationship of LILRA3 deletion with R-MS is not secondary to linkage disequilibrium with a KIR gene, but we cannot exclude some contributions of KIR to the genetic susceptibility to R-MS. 19421224 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE These data reveal that the GEM assay is a useful adjunct in the management of MS patients treated with IFNbeta, and that lost bioactivity returns when anti-IFNbeta antibody levels diminish. 16005084 2005